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Daniel G. Federman, MD; Robert S. Kirsner, MD

Arch Intern Med. 2001;161:1051-1056.

Venous thrombosis is a cause of considerable morbidity and is often responsible for chronic venous disorders that frequently lead to visits to dermatologists and others involved in wound healing. Over the past several years, many new causes of thrombophilia have been identified and have dramatically altered the approach to patients presenting with thrombosis. Newly described abnormalities associated with thrombophilia include the syndrome of activated protein C resistance, the prothrombin 20210A mutation, hyperhomocysteinemia, and elevated levels of coagulation factors VIII and XI. Clinicians can now frequently determine causes of thromboses that have previously been deemed idiopathic.

From the Department of Medicine, Yale University School of Medicine, New Haven, Conn, and Veterans Affairs Connecticut Health Care System, West Haven (Dr Federman); and Department of Dermatology and Cutaneous Surgery, Department of Epidemiology, University of Miami School of Medicine, Miami, Fla (Dr Kirsner).

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