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An Update on Hypercoagulable Disorders
Daniel G. Federman, MD;
Robert S. Kirsner, MD
Arch Intern Med. 2001;161:1051-1056.
Venous thrombosis is a cause of considerable morbidity and is often
responsible for chronic venous disorders that frequently lead to visits to
dermatologists and others involved in wound healing. Over the past several
years, many new causes of thrombophilia have been identified and have dramatically
altered the approach to patients presenting with thrombosis. Newly described
abnormalities associated with thrombophilia include the syndrome of activated
protein C resistance, the prothrombin 20210A mutation, hyperhomocysteinemia,
and elevated levels of coagulation factors VIII and XI. Clinicians can now
frequently determine causes of thromboses that have previously been deemed
idiopathic.
From the Department of Medicine, Yale University School of Medicine,
New Haven, Conn, and Veterans Affairs Connecticut Health Care System, West
Haven (Dr Federman); and Department of Dermatology and Cutaneous Surgery,
Department of Epidemiology, University of Miami School of Medicine, Miami,
Fla (Dr Kirsner).
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