This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (21)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Exercise  • Obesity  • Cardiovascular System  • Congestive Heart Failure/ Cardiomyopathy  • Hypertension  • Alert me on articles by topic  Social Bookmarking   What's this?

Alan Hinderliter, MD; Andrew Sherwood, PhD; Elizabeth C. D. Gullette, PhD; Michael Babyak, PhD; Robert Waugh, MD; Anastasia Georgiades, PhD; James A. Blumenthal, PhD

Arch Intern Med. 2002;162:1333-1339.

Background  Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, evidence that they have a beneficial effect on target organs has been lacking.

Objective  To assess the effects of regular aerobic exercise or exercise plus weight management counseling on left ventricular mass and geometry in overweight, sedentary men and women with high-normal or mildly elevated blood pressure.

Methods  Eighty-two participants in a randomized, controlled trial were assigned to supervised aerobic exercise only, a behavioral weight management program that included exercise, or a waiting-list control group for 6 months. Blood pressure and echocardiographic measures of left ventricular structure were measured at baseline and at the conclusion of the treatment phase.

Results  The 45 women and 37 men had a mean ± SD age of 47 ± 9 years and had a mean ± SD blood pressure of 140 ± 10/93 ± 5 mm Hg. Blood pressure fell by 7/6 mm Hg in the weight management group and by 3/4 mm Hg in the aerobic exercise group. In association with these decreases in blood pressure, participants in the intervention groups exhibited significant decreases in left ventricular relative wall thickness (P = .003), posterior wall thickness (P = .05), and septal thickness (P = .004) and a trend toward a decrease in indexed left ventricular mass (P = .08) relative to the control group.

Conclusions  In a cohort of overweight, sedentary men and women, exercise and weight loss reduced blood pressure and induced favorable changes in left ventricular structure.

From the Department of Medicine, University of North Carolina, Chapel Hill (Dr Hinderliter), and the Departments of Psychiatry and Behavioral Sciences (Drs Sherwood, Gullette, Babyak, Georgiades, and Blumenthal) and Medicine (Dr Waugh), Duke University Medical Center, Durham, NC.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

RELATED ARTICLE

Archives of Internal Medicine Reader's Choice: Continuing Medical Education
Arch Intern Med. 2002;162(12):1424.
FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Regular physical activity prevents development of left ventricular hypertrophy in hypertension
Palatini et al.
Eur Heart J 2009;30:225-232.
ABSTRACT | FULL TEXT  

Meta-analysis: The Effect of Dietary Counseling for Weight Loss
Dansinger et al.
ANN INTERN MED 2007;147:41-50.
ABSTRACT | FULL TEXT  

Determinants of coronary blood flow in humans: quantification by intracoronary Doppler and ultrasound
Wieneke et al.
J. Appl. Physiol. 2005;98:1076-1082.
ABSTRACT | FULL TEXT  

Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation
Klein et al.
Circulation 2004;110:2952-2967.
ABSTRACT | FULL TEXT  

The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study
Laukkanen et al.
Eur Heart J 2004;25:1428-1437.
ABSTRACT | FULL TEXT  

Comparison of effects of exercise and diuretic on left ventricular geometry, mass, and insulin resistance in older hypertensive adults
Rinder et al.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004;287:R360-R368.
ABSTRACT | FULL TEXT  

Obesity and hypertension: two epidemics or one?
Davy and Hall
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004;286:R803-R813.
ABSTRACT | FULL TEXT  

Adiposity Contributes to Differences in Left Ventricular Structure and Diastolic Function with Age in Healthy Men
Gates et al.
J. Clin. Endocrinol. Metab. 2003;88:4884-4890.
ABSTRACT | FULL TEXT  

Exercise plus Weight Loss to Reduce LV Hypertrophy in Overweight, Mildly Hypertensive Patients
Journal Watch Cardiology 2002;2002:3-3.
FULL TEXT