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A Case Report of Pentosan Polysulfate Sodium–Induced Coagulopathy

Sharlene Gill, MD; Sheldon C. Naiman, MD; Abeed Jamal, MD; Linda M. Vickars, MD

Arch Intern Med. 2002;162:1644-1645.

Pentosan polysulfate sodium (Elmiron; Alza Pharmaceuticals, Mountain View, Calif) is an oral preparation of pentosan polysulfate used in the symptomatic management of interstitial cystitis. While pentosan polysulfate has a known heparinlike effect in its parenteral form, there have been no previous reports of coagulopathy with oral use. We present an interesting case of inadvertent systemic anticoagulation resulting in serious bleeding complications in a young woman taking oral pentosan polysulfate for interstitial cystitis.

From the Department of Medicine, University of British Columbia (Drs Gill and Jamal); and the Division of Clinical Hematology, St Paul's Hospital (Drs Naiman and Vickars), Vancouver, British Columbia.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Misleading Report of Massive Bleeding in a Patient Taking Pentosan Polysulfate
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Arch Intern Med 2003;163:119-119.
FULL TEXT  

Misleading Report of Massive Bleeding in a Patient Taking Pentosan Polysulfate
Gill et al.
Arch Intern Med 2003;163:119-119.
FULL TEXT