
The Role of Hormone Replacement Therapy in the Prevention of Alzheimer Disease
Howard M. Fillit, MD
Arch Intern Med. 2002;162:1934-1942.
Alzheimer disease (AD) is the most common form of dementia among the
elderly. A higher prevalence of AD in women than in men suggests a link between
gonadal hormone levels and AD. Increasing evidence supports a role for estrogen
in brain regions involved in learning and memory and in the protection and
regulation of cholinergic neurons, which degenerate in AD. Despite the lack
of consensus, many studies indicate that hormone replacement therapy may decrease
the risk for or delay the onset of AD in postmenopausal women. Recent trials
have suggested that estrogen treatment may have no significant effect on the
clinical course of AD in elderly women with the disease. Thus, the role of
estrogen therapy seems to be confined to primary rather than secondary prevention
of AD. Ongoing clinical studies may help to determine the role of estrogen
in the cognitive function of postmenopausal women and in the prevention of
AD.
From The Institute for the Study of Aging, Inc, New York, NY.
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Neuroprotective effects of the Alzheimer's disease-related gene seladin-1
Peri and Serio
J Mol Endocrinol 2008;41:251-261.
ABSTRACT
| FULL TEXT
Estrogen and Selective Estrogen Receptor Modulators Exert Neuroprotective Effects and Stimulate the Expression of Selective Alzheimer's Disease Indicator-1, a Recently Discovered Antiapoptotic Gene, in Human Neuroblast Long-Term Cell Cultures
Benvenuti et al.
J. Clin. Endocrinol. Metab. 2005;90:1775-1782.
ABSTRACT
| FULL TEXT
Postmenopausal hormone therapy and risk of cognitive decline in community-dwelling aging women
Kang et al.
Neurology 2004;63:101-107.
ABSTRACT
| FULL TEXT
Copper Perturbation in 2 Monozygotic Twins Discordant for Degree of Cognitive Impairment
Squitti et al.
Arch Neurol 2004;61:738-743.
ABSTRACT
| FULL TEXT
Changes in endometrial blood vessels in the endometrium of women with hormone replacement therapy-related irregular bleeding
Hickey et al.
Hum Reprod 2003;18:1100-1106.
ABSTRACT
| FULL TEXT
Management of Alzheimer's Disease
Grossberg and Desai
Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2003;58:M331-353.
FULL TEXT
|