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Arch Intern Med. 2002;162:867-869.

We evaluate the suggestion that high-sensitivity C-reactive protein testing be used for risk assessment in the primary prevention of cardiovascular disease, using the criteria proposed by the Guide to Clinical Preventive Services developed by the US Preventive Services Task Force. We conclude that at present, none of the 3 major criteria—accuracy, reliability, and likelihood of beneficial intervention— are satisfied.

Irving Kushner, MD; Ashwini R. Sehgal, MD
From the Departments of Medicine (Drs Kushner and Sehgal), Pathology (Dr Kushner), and Epidemiology and Biostatistics (Dr Sehgal) and Center for Biomedical Ethics (Dr Sehgal), Case Western Reserve University; and Division of Nephrology and Center for Health Care Research and Policy, MetroHealth Medical Center (Dr Sehgal), Cleveland, Ohio.

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