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Celecoxib-Related Renal Papillary Necrosis
Laila Akhund, MD;
Robert J. Quinet, MD;
Saliha Ishaq, MD
Arch Intern Med. 2003;163:114-115.
Selective cyclooxygenase 2 (COX-2) inhibitors are known to affect renal prostaglandins (epoprostenol and dinoprostone), which are at least in part COX-2 dependent. Consequently, adverse events including hypertension, peripheral edema, hypercalemia, hyponatremia, and acute renal failure have been reported to occur with the new COX-2specific inhibitors. This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2specific inhibitors.
From the Department of Internal Medicine, Section on Rheumatology, Ochsner Clinic Foundation, New Orleans, La.
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