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From Genes to Treatment

Douglas S. Jacoby, MD; Daniel J. Rader, MD

Arch Intern Med. 2003;163:1155-1164.

The renin-angiotensin system plays a central role in the pathogenesis of cardiovascular disease. At the molecular and cellular levels, angiotensin II, the main effector peptide of the system, stimulates key components of atherosclerosis. Trials in animals and humans indicate that blocking renin-angiotensin system pathways decreases atherosclerotic plaque progression and ischemic events. This review provides a broad overview of the entire role of the renin-angiotensin system in atherothrombotic disease, ranging from molecular pathways to human genetics to the latest clinical trials.

From the Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Health System, Philadelphia. The authors have no relevant financial interest in this article.

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