 |
|
Cholesterol-Lowering Effect of a Theaflavin-Enriched Green Tea Extract
A Randomized Controlled Trial
David J. Maron, MD;
Guo Ping Lu, MD;
Nai Sheng Cai, MD;
Zong Gui Wu, MD;
Yue Hua Li, MD;
Hui Chen, MD;
Jian Qiu Zhu, MD;
Xue Juan Jin, MS;
Bert C. Wouters, MA;
Jian Zhao, PhD
Arch Intern Med. 2003;163:1448-1453.
Background Tea consumption has been associated with decreased cardiovascular risk, but potential mechanisms of benefit are ill-defined. While epidemiologic studies suggest that drinking multiple cups of tea per day lowers low-density lipoprotein cholesterol (LDL-C), previous trials of tea drinking and administration of green tea extract have failed to show any impact on lipids and lipoproteins in humans. Our objective was to study the impact of a theaflavin-enriched green tea extract on the lipids and lipoproteins of subjects with mild to moderate hypercholesterolemia.
Methods Double-blind, randomized, placebo-controlled, parallel-group trial set in outpatient clinics in 6 urban hospitals in China. A total of 240 men and women 18 years or older on a low-fat diet with mild to moderate hypercholesterolemia were randomly assigned to receive a daily capsule containing theaflavin-enriched green tea extract (375 mg) or placebo for 12 weeks. Main outcome measures were mean percentage changes in total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C), and triglyceride levels compared with baseline.
Results After 12 weeks, the mean ± SEM changes from baseline in total cholesterol, LDL-C, HDL-C, and triglyceride levels were -11.3% ± 0.9% (P = .01), -16.4% ± 1.1% (P = .01), 2.3% ± 2.1% (P = .27), and 2.6% ± 3.5% (P = .47), respectively, in the tea extract group. The mean levels of total cholesterol, LDL-C, HDL-C, and triglycerides did not change significantly in the placebo group. No significant adverse events were observed.
Conclusion The theaflavin-enriched green tea extract we studied is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated.
From the Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tenn (Dr Maron); Rui Jin Hospital, Shanghai, China (Dr Lu); Zhong Shan Hospital, Shanghai (Dr Cai and Ms Jin); Chang Zheng Hospital, Shanghai (Dr Wu); Xin Hua Hospital, Shanghai (Dr Li); Heart and Lung Hospital, Shanghai (Dr Chen); First Hospital, Wuxi, China (Dr Zhu); Nashai Biotech LLC, Nashville (Mr Wouters and Dr Zhao). Dr Maron is a consultant to Nashai Biotech, LLC. Mr Wouters was a Vice President of Nashai Biotech, LLC, when this study was conducted. Dr Zhao is the Chief Science Officer of Nashai Biotech, LLC. Drs Lu and Ms Jin received grants from Kebao Biotechnology Co, Ltd, Shanghai.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Parkinson's Disease and Tea: A Quantitative Review
Barranco Quintana et al.
J. Am. Coll. Nutr. 2009;28:1-6.
ABSTRACT
| FULL TEXT
The Relation between Green Tea Consumption and Cardiovascular Disease as Evidenced by Epidemiological Studies
Kuriyama
J. Nutr. 2008;138:1548S-1553S.
ABSTRACT
| FULL TEXT
Tea Consumption Is Inversely Associated With Carotid Plaques in Women
Debette et al.
Arterioscler. Thromb. Vasc. Bio. 2008;28:353-359.
ABSTRACT
| FULL TEXT
Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
Lin et al.
J. Lipid Res. 2007;48:2334-2343.
ABSTRACT
| FULL TEXT
Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects
Castilla et al.
Am. J. Clin. Nutr. 2006;84:252-262.
ABSTRACT
| FULL TEXT
Green Tea Polyphenols Modulate Insulin Secretion by Inhibiting Glutamate Dehydrogenase
Li et al.
J. Biol. Chem. 2006;281:10214-10221.
ABSTRACT
| FULL TEXT
Other articles noted: 25 Jul 03 to 7 Nov 03
Evid. Based Nurs. 2004;7:e1-1.
FULL TEXT
Do Tea Extracts Lower Cholesterol?
Journal Watch Cardiology 2003;2003:4-4.
FULL TEXT
Can Tea Extracts Lower Cholesterol?
JWatch General 2003;2003:2-2.
FULL TEXT
|
