 |
|
Effects of Exercise and Weight Loss on Cardiac Risk Factors Associated With Syndrome X
Lana L. Watkins, PhD;
Andrew Sherwood, PhD;
Mark Feinglos, MD;
Alan Hinderliter, MD;
Michael Babyak, PhD;
Elizabeth Gullette, PhD;
Robert Waugh, MD;
James A. Blumenthal, PhD
Arch Intern Med. 2003;163:1889-1895.
Background Patients with high blood pressure (BP) often exhibit syndrome X, an aggregation of abnormalities in carbohydrate and lipoprotein metabolism associated with increased risk of coronary heart disease (CHD). The present study evaluated the effects of a 6-month intervention involving either aerobic exercise training alone (EX only) or exercise combined with a structured weight loss program (EX + WL) on CHD risk factors associated with syndrome X.
Methods A total of 53 men and women were selected from a larger behavioral intervention trial, who showed the hyperinsulinemia, dyslipidemia, and high BP characteristic of syndrome X. Participants were randomly assigned to EX only (n = 21), EX + WL (n = 21), or a waiting list control group (n = 11). Before and following treatment, participants underwent measurement of glucose tolerance, lipid levels, and clinical BP.
Results Hyperinsulinemic responses to glucose challenge were significantly reduced in both the EX + WL group (P<.001) and the EX-only group (P = .003). Participants who showed the largest amount of weight loss showed the most robust improvements in abnormal insulin responses (EX + WL group, 47% reduction; EX-only group, 27% reduction). Diastolic BP was significantly reduced in the EX + WL group (96 ± 4 to 87 ± 5 mm Hg [mean ± SD]; P = .01), but not in the EX-only group (93 ± 4 to 89 ± 5 mm Hg [mean ± SD]; P = .08). Lipid profile was not significantly improved by either intervention.
Conclusion These results suggest that EX + WL is an effective treatment for hyperinsulinemia and lowering of diastolic BP in patients with the syndrome X.
From the Departments of Psychiatry and Behavioral Sciences (Drs Watkins, Sherwood, Babyak, Gullette, and Blumenthal) and Medicine (Drs Feinglos and Waugh), Duke University Medical Center, Durham, NC; and the Department of Medicine, University of North Carolina, Chapel Hill (Dr Hinderliter). The authors have no relevant financial interest in this article.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Effects of Exercise and Caloric Restriction on Insulin Resistance and Cardiometabolic Risk Factors in Older Obese Adults--A Randomized Clinical Trial
Yassine et al.
J Gerontol A Biol Sci Med Sci 2009;0:gln032v1-gln032.
ABSTRACT
| FULL TEXT
Longitudinal Change in Coronary Heart Disease Risk Factors in Older Runners
Schroeder et al.
Age Ageing 2007;36:57-62.
ABSTRACT
| FULL TEXT
Insulin Resistance and Atherosclerosis
Nigro et al.
Endocr. Rev. 2006;27:242-259.
ABSTRACT
| FULL TEXT
Behavioral treatment of obesity
Foster et al.
Am. J. Clin. Nutr. 2005;82:230S-235S.
ABSTRACT
| FULL TEXT
Assessing the Predictive Accuracy of QUICKI as a Surrogate Index for Insulin Sensitivity Using a Calibration Model
Chen et al.
Diabetes 2005;54:1914-1925.
ABSTRACT
| FULL TEXT
Long-Term Effects of Low-Calorie Diet on the Metabolic Syndrome in Obese Nondiabetic Patients
Muzio et al.
Diabetes Care 2005;28:1485-1486.
FULL TEXT
Development of Fatness, Fitness, and Lifestyle From Adolescence to the Age of 36 Years: Determinants of the Metabolic Syndrome in Young Adults: The Amsterdam Growth and Health Longitudinal Study
Ferreira et al.
Arch Intern Med 2005;165:42-48.
ABSTRACT
| FULL TEXT
Effects of exercise and diet on chronic disease
Roberts and Barnard
J. Appl. Physiol. 2005;98:3-30.
ABSTRACT
| FULL TEXT
JournalScan
Malik
Heart 2003;89:1467-1468.
FULL TEXT
|
