This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (40)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Bacterial Infections  • Alert me on articles by topic  Social Bookmarking   What's this?

Didier Raoult, MD, PhD; Pierre-Edouard Fournier, MD, PhD; François Vandenesch, MD, PhD; Jean-Luc Mainardi, MD, PhD; Susannah J. Eykyn, FRCP, FRCS, FRCPath; James Nash, MD; Edward James, MD; Catherine Benoit-Lemercier, MD; Thomas J. Marrie, MD

Arch Intern Med. 2003;163:226-230.

Background  Endocarditis caused by Bartonella species is a potentially lethal infection characterized by a subacute evolution and severe valvular lesions.

Objectives  To evaluate the outcome of patients with Bartonella endocarditis and to define the best antibiotic regimen using the following measures: recovery, relapse, or death.

Methods  We performed a retrospective study on 101 patients who were diagnosed in our laboratory as having Bartonella endocarditis between January 1, 1995, and April 30, 2001. Bartonella infection was diagnosed using immunofluorescence with a 1:800 cutoff, polymerase chain reaction amplification of DNA, and/or culture findings of Bartonella species from whole blood, serum, and/or valvular biopsy specimens. A standardized questionnaire was completed by investigators for each patient.

Results  Twelve of the 101 patients died and 2 relapsed. Patients receiving an aminoglycoside were more likely to fully recover (P = .02), and those treated with aminoglycosides for at least 14 days were more likely to survive than those with shorter therapy duration (P = .02).

Conclusion  Effective antibiotic therapy for Bartonella endocarditis should include an aminoglycoside prescribed for a minimum of 2 weeks.

From the Unité des Rickettsies, Faculté de Médecine, Université de la Méditerranée, Marseille, France; (Drs Raoult and Fournier); Laboratoire de Microbiologie, Hôpital Edouard Herriot, Lyon, France; (Dr Vandenesch); Service de Microbiologie, Hôpital Georges Pompidou (Dr Mainardi), and Laboratoire de Microbiologie, Hôpital Bichat (Dr Benoit-Lemercier), Paris, France; Department of Infection, St Thomas' Hospital (Dr Eykyn), and Microbiology Department, St Bartholomew's Hospital (Dr James), London, England; Public Health Laboratory Service, William Harvey Hospital, Willesborough, Ashford, England; (Dr Nash); and Department of Medicine, University of Alberta, Edmonton (Dr Marrie).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Bartonella endocarditis complicating congenital heart disease
Al-Attar et al.
BMJ Case Reports 2009;2009:bcr0620080092-bcr0620080092.
ABSTRACT | FULL TEXT  

Urban trench fever presenting as culture-negative endocarditis
Jenkins et al.
QJM 2009;102:63-65.
ABSTRACT | FULL TEXT  

Beyond Cat Scratch Disease: Widening Spectrum of Bartonella henselae Infection
Florin et al.
Pediatrics 2008;121:e1413-e1425.
ABSTRACT | FULL TEXT  

Molecular Method for Bartonella Species Identification in Clinical and Environmental Samples
Garcia-Esteban et al.
J. Clin. Microbiol. 2008;46:776-779.
ABSTRACT | FULL TEXT  

Bivalvular Bartonella henselae Prosthetic Valve Endocarditis
Vikram et al.
J. Clin. Microbiol. 2007;45:4081-4084.
ABSTRACT | FULL TEXT  

Molecular mechanisms of resistance to antibiotics in Bartonella bacilliformis
Biswas et al.
J Antimicrob Chemother 2007;59:1065-1070.
ABSTRACT | FULL TEXT  

Epidemiology and antibiotic treatment of infective endocarditis: an update.
Hoen
Heart 2006;92:1694-1700.
FULL TEXT  

In vitro susceptibility of Bartonella species to 17 antimicrobial compounds: comparison of Etest and agar dilution
Dorbecker et al.
J Antimicrob Chemother 2006;58:784-788.
ABSTRACT | FULL TEXT  

MOLECULAR DETECTION OF BARTONELLA QUINTANA, B. ELIZABETHAE, B. KOEHLERAE, B. DOSHIAE, B. TAYLORII, AND RICKETTSIA FELIS IN RODENT FLEAS COLLECTED IN KABUL, AFGHANISTAN.
MARIE et al.
Am J Trop Med Hyg 2006;74:436-439.
ABSTRACT | FULL TEXT  

First Isolation of Bartonella alsatica from a Valve of a Patient with Endocarditis
Raoult et al.
J. Clin. Microbiol. 2006;44:278-279.
ABSTRACT | FULL TEXT  

HIGH PREVALENCE OF BARTONELLA QUINTANA ENDOCARDITIS IN SFAX, TUNISIA
ZNAZEN et al.
Am J Trop Med Hyg 2005;72:503-507.
ABSTRACT | FULL TEXT  

PCR Detection of Bacteria on Cardiac Valves of Patients with Treated Bacterial Endocarditis
Rovery et al.
J. Clin. Microbiol. 2005;43:163-167.
ABSTRACT | FULL TEXT  

Guidelines for the antibiotic treatment of endocarditis in adults: report of the Working Party of the British Society for Antimicrobial Chemotherapy
Elliott et al.
J Antimicrob Chemother 2004;54:971-981.
ABSTRACT | FULL TEXT  

Bartonella koehlerae, a New Cat-Associated Agent of Culture-Negative Human Endocarditis
Avidor et al.
J. Clin. Microbiol. 2004;42:3462-3468.
ABSTRACT | FULL TEXT  

Recommendations for Treatment of Human Infections Caused by Bartonella Species
Rolain et al.
Antimicrob. Agents Chemother. 2004;48:1921-1933.
FULL TEXT  

Culture-Negative Endocarditis Due to Houston Complex Bartonella henselae Acquired in Noumea, New Caledonia
Rodrick et al.
J. Clin. Microbiol. 2004;42:1846-1848.
ABSTRACT | FULL TEXT  

Pericardial Effusion in a Homeless Man Due to Bartonella quintana
Levy et al.
J. Clin. Microbiol. 2003;41:5291-5293.
ABSTRACT | FULL TEXT  

Isolation of Bartonella washoensis from a Dog with Mitral Valve Endocarditis
Chomel et al.
J. Clin. Microbiol. 2003;41:5327-5332.
ABSTRACT | FULL TEXT  

Fatal Case of Endocarditis Associated with Bartonella henselae Type I Infection in a Domestic Cat
Chomel et al.
J. Clin. Microbiol. 2003;41:5337-5339.
ABSTRACT | FULL TEXT