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Samy I. McFarlane, MD; Nathaniel Winer, MD; James R. Sowers, MD

Arch Intern Med. 2003;163:2696-2704.

Significant progress has been made in the understanding of the neurohormonal factors that contribute to the progression of chronic renal and cardiac failure and the development of target-organ damage in patients with hypertension and diabetes.^1-3 We herein review some of these advances, including a new therapeutic strategy for potentially enhancing cardiorenal protection in patients with these disorders.

From the Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, State University of New York Health Science Center at Brooklyn and Kings County Hospital Centers of Brooklyn. The authors have no relevant financial interest in this article.