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Echinacea and Truth in Labeling
Christine M. Gilroy, MD;
John F. Steiner, MD, MPH;
Tim Byers, MD, MPH;
Howard Shapiro, PhD;
William Georgian, MS
Arch Intern Med. 2003;163:699-704.
Background Echinacea sales represent 10% of the dietary supplement market in the United States, but there is no guarantee as to the content, quality, variability, or contamination in Echinacea preparations.
Objective To qualitatively and quantitatively assess the contents of Echinacea-only preparations available in a retail setting.
Methods One of each single-herb Echinacea preparations that were available in August 2000 was obtained from several stores in the Denver, Colo, area. Thin-layer chromatography (TLC) was used to determine species and measure quantity. From this information, accuracy of species labeling and comparison of constituent to labeled content were assessed. The samples were stratified by whether they were labeled as standardized, and the standardized and nonstandardized samples were compared by ratio of constituent to labeled content.
Results Of the samples, 6 (10%) of 59 preparations contained no measurable Echinacea. The assayed species content was consistent with labeled content in 31 (52%) of the samples. Of the 21 standardized preparations, 9 (43%) met the quality standard described on the label. Labeled milligrams were weakly associated with measured constituent (r = 0.35; P = .02).
Conclusions Echinacea from retail stores often does not contain the labeled species. A claim of "standardization" does not mean the preparation is accurately labeled, nor does it indicate less variability in concentration of constituents of the herb.
From the Departments of General Internal Medicine (Drs Gilroy and Steiner), Preventive Medicine and Biometrics (Dr Byers), Preventive Medicine and Biometrics (Dr Shapiro), University of Colorado Health Sciences Center, Denver; HealthONE Alliance, Denver (Drs Gilroy and Shapiro); and S&W Microchemical, East Lyme, Conn (Mr Georgian). The authors have no relevant financial interest in this article.
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