 |
|
Effect of 1-Year Oral Administration of Dehydroepiandrosterone to 60- to 80-Year-Old Individuals on Muscle Function and Cross-sectional Area
A Double-blind Placebo-Controlled Trial
Gaëlle Percheron, PhD;
Jean-Yves Hogrel, PhD;
Sonjà Denot-Ledunois, PhD;
Guillemette Fayet, MD;
Françoise Forette, MD, PhD;
Etienne-Emile Baulieu, MD, PhD;
Michel Fardeau, MD;
Jean-François Marini, PhD
Arch Intern Med. 2003;163:720-727.
Background The age-related decline of dehydroepiandrosterone and its sulfate ester levels is thought to be related to the development of age-associated usual modifications, such as neuromuscular function impairments. It is often claimed that individuals can enhance their muscular capacity by boosting dehydroepiandrosterone levels through oral supplementation. However, to our knowledge, there have been no controlled studies on a significant number of individuals demonstrating positive effects on the neuromuscular system. This study determines if 1-year administration of a replacement dose of dehydroepiandrosterone, 50 mg/d, orally administered, could have a beneficial influence on several determinants of the muscular function altered during aging.
Methods This work was completed within the frame of the DHEAge Study, which was conducted in France from March 1, 1998, to October 31, 1999. It was performed on 280 healthy ambulatory and independent men and women aged 60 to 80 years. The study design was a double-blind placebo-controlled trial. Dehydroepiandrosterone sulfate serum concentration, handgrip strength, isometric and isokinetic knee muscle strength, and thigh (fat and muscle) cross-sectional area were analyzed before and just after 12 months of placebo or dehydroepiandrosterone treatment.
Results The results give evidence that dehydroepiandrosterone administration restores dehydroepiandrosterone sulfate serum concentrations to the normal range for young adults (aged 20-50 years). However, no positive effect inherent to dehydroepiandrosterone treatment was observed either on muscle strength or in muscle and fat cross-sectional areas.
Conclusions The compensation of the deficit of dehydroepiandrosterone during aging using a 50-mg/d dose does not induce beneficial effects on muscle state in healthy subjects. The conditions in which dehydroepiandrosterone could contribute to preserve or improve muscle strength and morphological features still need to be determined.
From the Institut de Myologie (Drs Percheron, Hogrel, Denot-Ledunois, Fayet, and Fardeau) and the Fondation Nationale de Gérontologie (Dr Forette), Paris, INSERM Unité 488, Le Kremlin-Bicêtre (Dr Baulieu), and CNRS, Unité Mixte de Recherche 6548, Université de Nice, Nice (Dr Marini), France.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
DHEA enhances effects of weight training on muscle mass and strength in elderly women and men
Villareal and Holloszy
Am. J. Physiol. Endocrinol. Metab. 2006;291:E1003-E1008.
ABSTRACT
| FULL TEXT
Aging and Fountain-of-Youth Hormones
Stewart
NEJM 2006;355:1724-1726.
FULL TEXT
DHEAS Levels and Mortality in Disabled Older Women: The Women's Health and Aging Study I.
Cappola et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2006;61:957-962.
ABSTRACT
| FULL TEXT
Dehydroepiandrosterone (DHEA)
Obstet Gynecol 2005;106:1096-1097.
FULL TEXT
The Art and Science of Anti-Aging Therapies
Trojanowski et al.
Sci Aging Knowl Environ 2005;2005:pe11-pe11.
ABSTRACT
| FULL TEXT
Steroid sulfatase gene variation and DHEA responsiveness to resistance exercise in MERET
Riechman et al.
Physiol. Genomics 2004;17:300-306.
ABSTRACT
| FULL TEXT
Is the Hormonal Fountain of Youth Drying Up?
Morley
J. Gerontol. A Biol. Sci. Med. Sci. 2004;59:M458-M460.
FULL TEXT
Effect of DHEAS on Skeletal Muscle Over the Life Span: The InCHIANTI Study
Valenti et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2004;59:M466-M472.
ABSTRACT
| FULL TEXT
|
