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John G. O'Meara, PharmD; Sharon L. R. Kardia, PhD; Jeffrey J. Armon, PharmD; C. Andrew Brown, MD; Eric Boerwinkle, PhD; Stephen T. Turner, MD

Arch Intern Med. 2004;164:1313-1318.

Background  Two ethnically different, community-based samples of hypertensive adults were evaluated to determine the prevalence of dyslipidemia and how often dyslipidemia is drug-treated and controlled by such treatment.

Methods  We studied 1286 non-Hispanic black hypertensive subjects from Jackson and 1070 non-Hispanic white hypertensive subjects from Rochester who participated in the Genetic Epidemiology Network of Arteriopathy study. Subjects were categorized according to presence of coronary heart disease and risk factors for coronary heart disease.

Results  Prevalence of dyslipidemia was significantly greater among whites than blacks (women, 64.7% vs 49.5%; and men, 78.4% vs 56.7%; P<.001 for both) and among men than women (P.02 in each ethnic group). Among dyslipidemic subjects, treatment with lipid-regulating drugs was significantly more common among whites than blacks (women, 25.4% vs 16.4%, P = .001; and men, 32.6% vs 12.8%; P<.001), and among whites, treatment was significantly more common among men than women (P = .03). With drug treatment, control of dyslipidemia varied from 33.9% (white men) to 51.9% (black men), but the differences among ethnic-sex groups were not statistically significant.

Conclusions  Dyslipidemia is highly prevalent in hypertensive adults. Fewer than one third of these adults are drug-treated, and fewer than half of those treated achieve recommended goals. Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.

From the Department of Pharmacy Services (Drs O'Meara and Armon) and Division of Nephrology and Hypertension, Department of Internal Medicine (Dr Turner), Mayo Clinic and Foundation, Rochester, Minn; Department of Epidemiology, University of Michigan, Ann Arbor (Dr Kardia); Department of Internal Medicine, University of Mississippi, Jackson (Dr Brown); and Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston (Dr Boerwinkle). The authors have no relevant financial interest in this article.

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