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  Vol. 164 No. 14, July 26, 2004 TABLE OF CONTENTS
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Difficult End-of-Life Treatment Decisions

Do Other Factors Trump Advance Directives?

Steven B. Hardin, MD; Yasmin A. Yusufaly, MD

Arch Intern Med. 2004;164:1531-1533.

Background  Advance directives are widely promoted as a means to plan for patients' decisional incapacity, yet there is little evidence of their effectiveness. We devised a study to assess physicians' compliance with hypothetical advance directives and further examine their clinical reasoning.

Methods  The study consisted of an analysis of a mailed written survey containing 6 hypothetical cases of seriously ill patients. Each case contained an explicit advance directive with potential conflict between the directive and (1) prognosis, (2) wishes of family or friends, or (3) quality of life. Data were collected on the clinical treatment decisions made by physicians and the reasons for those decisions. Study participants were all internal medicine faculty and resident physicians from a single academic institution.

Results  A total of 47% analyzable surveys (117/250) were returned. Decisions by faculty and residents were not consistent with the advance directive in 65% of cases. This inconsistency was similar for faculty and residents (68% and 61%, respectively; P>.05). When physicians made decisions inconsistent with the advance directive, they were more likely to list reasons other than the directive for their decisions (89%; P<.001).

Conclusions  Internists frequently made treatment decisions that were not consistent with an explicit advance directive. In difficult clinical situations, internists appear to consider other factors such as prognosis, perceived quality of life, and the wishes of family or friends as more determinative than the directive. Future work needs to explore the generalizability of these findings and examine how strictly patients desire their advance directives to be followed.


From the Jerry L. Pettis Memorial Veterans Affairs Medical Center and the Department of Internal Medicine, Loma Linda University School of Medicine, Loma Linda, Calif. The authors have no relevant financial interest in this article.



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