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Use of Oral Topiramate to Promote Smoking Abstinence Among Alcohol-Dependent Smokers
A Randomized Controlled Trial
Bankole A. Johnson, DSc, MD, PhD;
Nassima Ait-Daoud, MD;
Fatema Z. Akhtar, MS;
Martin A. Javors, PhD
Arch Intern Med. 2005;165:1600-1605.
Background Previously, our group has shown that topiramate, a sulfamate-substituted fructopyranose derivative, is an effective treatment for alcohol dependence. Herein, we extend that proof-of-concept study by determining whether cigarette-smoking, alcohol-dependent individuals from the earlier study also experienced improved smoking outcomes.
Methods As a subgroup analysis of a larger double-blind, randomized, controlled, 12-week study comparing topiramate vs placebo as treatment for alcohol dependence, a 12-week clinical trial compared topiramate vs placebo in 94 cigarette-smoking, alcohol-dependent individuals. Of these, 45 were assigned to receive topiramate (escalating dose from 25 to 300 mg/d) and the remaining 49 had placebo as an adjunct to weekly standardized medication compliance management. The primary outcome was smoking cessation ascertained by self-report and confirmed by the level of serum cotinine (nicotine’s major metabolite).
Results Topiramate recipients were significantly more likely than placebo recipients to abstain from smoking (odds ratio, 4.46; 95% confidence interval, 1.08-18.39; P = .04). Using a serum cotinine level of 28 ng/mL or lower to segregate nonsmokers from smokers, we found that the topiramate group had 4.97 times the odds of being nonsmokers (95% confidence interval, 1.1-23.4;P = .04). Smoking cessation rates for topiramate recipients were 19.4% and 16.7% at weeks 9 and 12, respectively, compared with 6.9% at both time points for placebo recipients.
Conclusion In this trial, topiramate (up to 300 mg/d) showed potential as a safe and promising medication for the treatment of cigarette smoking in alcohol-dependent individuals.
Author Affiliations: Department of Psychiatric Medicine, University of Virginia, Charlottesville (Drs Johnson and Ait-Daoud); and Departments of Psychiatry (Ms Akhtar) and Pharmacology (Dr Javors), The University of Texas Health Science Center at San Antonio.
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