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Differences in Screening Mammography Outcomes Among White, Chinese, and Filipino Women
Karla Kerlikowske, MD;
Jennifer Creasman, MSPH;
Jessica W. T. Leung, MD;
Rebecca Smith-Bindman, MD;
Virginia L. Ernster, PhD
Arch Intern Med. 2005;165:1862-1868.
Background The accuracy of screening mammography among Asian women in the United States has received little attention. We determined whether the accuracy of screening mammography for Chinese and Filipino women differs from that of white women.
Methods We examined a cohort of white, Chinese, and Filipino women 40 years and older who underwent 200 402, 72 604, and 19 087 screening examinations, respectively, between January 1986 and December 2001 in San Francisco County, California, of whom 2177 were diagnosed with breast cancer within 12 months of a screening examination. By linking screening examinations to the regional Surveillance, Epidemiology and End Results program and the California Cancer Registry, we identified the occurrence of any invasive cancer or ductal carcinoma in situ and then calculated the rate of cancer per 1000 screenings and the sensitivity of mammography.
Results The rate of invasive breast cancer per 1000 screenings was 45% lower for Chinese than for white women aged 50 to 69 years (3.8 vs 6.9; P<.001) and 29% lower for Filipino than for white women (4.9 vs 6.9; P = .03). Rates of ductal carcinoma in situ were similar across all ethnic groups (1.6-1.7 per 1000 screenings; P .60). The sensitivity of mammography was similar for white, Chinese, and Filipino women (81.6%-84.3%; P>.30).
Conclusions Screening mammography has similar accuracy among white, Chinese, and Filipino women, although the absolute benefit of screening, in terms of breast cancer deaths averted, is likely to be less among Asian women because the rates of invasive cancer are lower compared with white women of similar age. Overdiagnosis of ductal carcinoma in situ with screening mammography among Asian women is likely to be comparable to that of white women because the rate of ductal carcinoma in situ was similar in all the examined ethnic groups.
Author Affiliations: Departments of Epidemiology and Biostatistics (Drs Kerlikowske, Smith-Bindman, and Ernster), Medicine (Dr Kerlikowske and Ms Creasman), and Radiology (Drs Leung and Smith-Bindman), and General Internal Medicine Section, Department of Veterans Affairs (Dr Kerlikowske), University of California, San Francisco.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Does utilization of screening mammography explain racial and ethnic differences in breast cancer?
Smith-Bindman et al.
ANN INTERN MED 2006;144:541-553.
ABSTRACT
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