This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (35)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Otolaryngology/ Head & Neck Surgery  • Sleep Apnea  • Alert me on articles by topic  Social Bookmarking   What's this?

The Sleep Heart Health Study

Anne B. Newman, MD, MPH; Greg Foster, MA; Rachel Givelber, MD; F. Javier Nieto, MD, PhD; Susan Redline, MD; Terry Young, PhD

Arch Intern Med. 2005;165:2408-2413.

Background  The relationship of weight changes to the incidence, progression, and remission of sleep-disordered breathing (SDB) is not well defined. This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography.

Methods  We performed a longitudinal cohort study of the cardiovascular consequences of sleep apnea in diverse US communities. Sleep apnea and polysomnographic indicators of SDB were assessed 5 years apart.

Results  A total of 2968 men and women (mean age, 62 years) participated in the study. Men were more likely to have an increase in Respiratory Disturbance Index (RDI) with a given increase in weight than were women, and this was not explained by differences in starting weight, waist circumference, age, or ethnicity. In a linear regression analysis, both men and women had a greater increase in RDI with weight gain than a decrease in RDI with weight loss. In a categorical analysis of larger degrees of change, this sex difference was also evident. Associations were similar in diverse ethnic groups. However, SDB progressed over time, even in those with stable weight.

Conclusion  Modest changes in weight were related to an increase or decrease in SDB, and this association was stronger in men than in women.

Author Affiliations: Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pa (Drs Newman and Givelber); Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Md (Mr Foster); Department of Population Health Sciences, University of Wisconsin, Madison (Drs Nieto and Young); and Department of Medicine, Case Western Reserve University, Cleveland, Ohio (Dr Redline). Mr Foster is currently with MedStar Research Institute, Hyattsville, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Exercise Capacity and Obstructive Sleep Apnea in Lean Subjects
Rizzi et al.
Chest 2010;137:109-114.
ABSTRACT | FULL TEXT  

Natural history and predictors for progression of mild childhood obstructive sleep apnoea
Li et al.
Thorax 2010;65:27-31.
ABSTRACT | FULL TEXT  

Effect of a very low energy diet on moderate and severe obstructive sleep apnoea in obese men: a randomised controlled trial
Johansson et al.
BMJ 2009;339:b4609-b4609.
ABSTRACT | FULL TEXT  

Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing
Chami et al.
Vasc Med 2009;14:351-360.
ABSTRACT  

The Impact of Obesity on Oxygen Desaturation during Sleep-disordered Breathing
Peppard et al.
Am. J. Respir. Crit. Care Med. 2009;180:788-793.
ABSTRACT | FULL TEXT  

A Randomized Study on the Effect of Weight Loss on Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes: The Sleep AHEAD Study
Foster et al.
Arch Intern Med 2009;169:1619-1626.
ABSTRACT | FULL TEXT  

Epidemiology of sleep apnoea/hypopnoea syndrome and sleep-disordered breathing
Jennum and Riha
Eur Respir J 2009;33:907-914.
ABSTRACT | FULL TEXT  

Obstructive sleep apnoea and its association with gestational hypertension
Champagne et al.
Eur Respir J 2009;33:559-565.
ABSTRACT | FULL TEXT  

Lifestyle Intervention with Weight Reduction: First-line Treatment in Mild Obstructive Sleep Apnea
Tuomilehto et al.
Am. J. Respir. Crit. Care Med. 2009;179:320-327.
ABSTRACT | FULL TEXT  

Progression of snoring and obstructive sleep apnoea: the role of increasing weight and time
Berger et al.
Eur Respir J 2009;33:338-345.
ABSTRACT | FULL TEXT  

Sleep, Sleep Disorders, and the Endocrine System
Vorona
ACCP Sleep Med Brd Rev 2009;4:163-184.
FULL TEXT  

Impaired cerebral autoregulation in obstructive sleep apnea
Urbano et al.
J. Appl. Physiol. 2008;105:1852-1857.
ABSTRACT | FULL TEXT  

Obesity and Persisting Sleep Apnea After Adenotonsillectomy in Greek Children
Apostolidou et al.
Chest 2008;134:1149-1155.
ABSTRACT | FULL TEXT  

Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age
Schwartz et al.
Eur Respir J 2008;32:255-258.
FULL TEXT  

The Association of Testosterone Levels with Overall Sleep Quality, Sleep Architecture, and Sleep-Disordered Breathing
Barrett-Connor et al.
J. Clin. Endocrinol. Metab. 2008;93:2602-2609.
ABSTRACT | FULL TEXT  

Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep
Kirkness et al.
J. Appl. Physiol. 2008;104:1618-1624.
ABSTRACT | FULL TEXT  

The Epidemiology of Adult Obstructive Sleep Apnea
Punjabi
Proc Am Thorac Soc 2008;5:136-143.
ABSTRACT | FULL TEXT  

Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Schwartz et al.
Proc Am Thorac Soc 2008;5:185-192.
ABSTRACT | FULL TEXT  

Effects of Continuous Positive Airway Pressure on Cerebral Vascular Response to Hypoxia in Patients with Obstructive Sleep Apnea
Foster et al.
Am. J. Respir. Crit. Care Med. 2007;175:720-725.
ABSTRACT | FULL TEXT  

Pediatric Sleep Apnea: Implications of the Epidemic of Childhood Overweight
Ievers-Landis and Redline
Am. J. Respir. Crit. Care Med. 2007;175:436-441.
ABSTRACT | FULL TEXT  

Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
McNicholas et al.
Eur Respir J 2007;29:156-178.
ABSTRACT | FULL TEXT  

Longitudinal Study of Risk Factors for Habitual Snoring in a General Adult Population: The Busselton Health Study
Knuiman et al.
Chest 2006;130:1779-1783.
ABSTRACT | FULL TEXT  

Sleep disruption is related to allelic variation in the ob gene
Lydic
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006;290:R892-R893.
FULL TEXT