 |
 |

Progression and Regression of Sleep-Disordered Breathing With Changes in Weight
The Sleep Heart Health Study
Anne B. Newman, MD, MPH;
Greg Foster, MA;
Rachel Givelber, MD;
F. Javier Nieto, MD, PhD;
Susan Redline, MD;
Terry Young, PhD
Arch Intern Med. 2005;165:2408-2413.
Background The relationship of weight changes to the incidence, progression, and remission of sleep-disordered breathing (SDB) is not well defined. This study aims to determine the relationship between change in weight and progression or remission of SDB by polysomnography.
Methods We performed a longitudinal cohort study of the cardiovascular consequences of sleep apnea in diverse US communities. Sleep apnea and polysomnographic indicators of SDB were assessed 5 years apart.
Results A total of 2968 men and women (mean age, 62 years) participated in the study. Men were more likely to have an increase in Respiratory Disturbance Index (RDI) with a given increase in weight than were women, and this was not explained by differences in starting weight, waist circumference, age, or ethnicity. In a linear regression analysis, both men and women had a greater increase in RDI with weight gain than a decrease in RDI with weight loss. In a categorical analysis of larger degrees of change, this sex difference was also evident. Associations were similar in diverse ethnic groups. However, SDB progressed over time, even in those with stable weight.
Conclusion Modest changes in weight were related to an increase or decrease in SDB, and this association was stronger in men than in women.
Author Affiliations: Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pa (Drs Newman and Givelber); Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Md (Mr Foster); Department of Population Health Sciences, University of Wisconsin, Madison (Drs Nieto and Young); and Department of Medicine, Case Western Reserve University, Cleveland, Ohio (Dr Redline). Mr Foster is currently with MedStar Research Institute, Hyattsville, Md.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age
Schwartz et al.
Eur Respir J 2008;32:255-258.
FULL TEXT
The Association of Testosterone Levels with Overall Sleep Quality, Sleep Architecture, and Sleep-Disordered Breathing
Barrett-Connor et al.
J. Clin. Endocrinol. Metab. 2008;93:2602-2609.
ABSTRACT
| FULL TEXT
Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep
Kirkness et al.
J. Appl. Physiol. 2008;104:1618-1624.
ABSTRACT
| FULL TEXT
The Epidemiology of Adult Obstructive Sleep Apnea
Punjabi
Proc Am Thorac Soc 2008;5:136-143.
ABSTRACT
| FULL TEXT
Obesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Schwartz et al.
Proc Am Thorac Soc 2008;5:185-192.
ABSTRACT
| FULL TEXT
Effects of Continuous Positive Airway Pressure on Cerebral Vascular Response to Hypoxia in Patients with Obstructive Sleep Apnea
Foster et al.
Am. J. Respir. Crit. Care Med. 2007;175:720-725.
ABSTRACT
| FULL TEXT
Pediatric Sleep Apnea: Implications of the Epidemic of Childhood Overweight
Ievers-Landis and Redline
Am. J. Respir. Crit. Care Med. 2007;175:436-441.
ABSTRACT
| FULL TEXT
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
McNicholas et al.
Eur Respir J 2007;29:156-178.
ABSTRACT
| FULL TEXT
Longitudinal Study of Risk Factors for Habitual Snoring in a General Adult Population: The Busselton Health Study
Knuiman et al.
Chest 2006;130:1779-1783.
ABSTRACT
| FULL TEXT
Sleep disruption is related to allelic variation in the ob gene
Lydic
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006;290:R892-R893.
FULL TEXT
|