• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (44)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Rheumatology  • Alert me on articles by topic  Social Bookmarking   What's this?

The Hordaland Homocysteine Study

Clara Gram Gjesdal, MD; Stein Emil Vollset, MD, DrPH; Per Magne Ueland, MD, PhD; Helga Refsum, MD, PhD; Christian A. Drevon, MD, PhD; Håkon K. Gjessing, PhD; Grethe S. Tell, PhD

Arch Intern Med. 2006;166:88-94.

Background  Plasma total homocysteine (tHcy) has been associated with hip fracture but not directly with bone mineral density (BMD). We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B₁₂ and the methylenetetrahydrofolate reductase (MTHFR) 677CT and 1298AC polymorphisms.

Methods  Bone mineral density was measured between 1997 and 2000 in 2268 men and 3070 women, aged 47 to 50 and 71 to 75 years, from the Hordaland Homocysteine Study cohort. Low BMD was defined as BMD in the lowest quintile for each sex and age group. Linear, logistic, and generalized additive regression models were used.

Results  Plasma levels of tHcy were inversely related to BMD among middle-aged and elderly women (P<.001) but not among men. The multiple adjusted odds ratio for low BMD among subjects with high (15 µmol/L [2.02 mg/L]) compared with low (<9 µmol/L [<1.22 mg/L]) tHcy level was 1.96 (95% confidence interval, 1.40-2.75) for women and was not significant for men. Additional adjustments for plasma folate level or intake of calcium and vitamin D did not substantially alter the results. Plasma folate level was associated with BMD in women only. We observed no association between BMD and vitamin B₁₂ level or the MTHFR polymorphisms.

Conclusions  Elevated tHcy and low folate levels were associated with reduced BMD in women but not in men. These findings suggest that tHcy may be a potential modifiable risk factor for osteoporosis in women.

Author Affiliations: Department of Public Health and Primary Health Care (Drs Gjesdal, Vollset, Gjessing, and Tell), LOCUS for Homocysteine and Related Vitamins (Drs Vollset, Ueland, and Tell), and Section of Pharmacology, Institute of Medicine (Drs Ueland and Refsum), University of Bergen, and Department of Rheumatology, Haukeland University Hospital (Dr Gjesdal), Bergen, Norway; Department of Pharmacology, University of Oxford, Oxford, England (Dr Refsum); and Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo (Dr Drevon), and Norwegian Institute of Public Health (Dr Gjessing), Oslo, Norway.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Homocysteine Levels and Risk of Hip Fracture in Postmenopausal Women
LeBoff et al.
J. Clin. Endocrinol. Metab. 2009;94:1207-1213.
ABSTRACT | FULL TEXT  

Demographic, Lifestyle, and Health Characteristics and Serum B Vitamin Status Are Determinants of Plasma Total Homocysteine Concentration in the Post-Folic Acid Fortification Period, 1999-2004
Ganji and Kafai
J. Nutr. 2009;139:345-352.
ABSTRACT | FULL TEXT  

Dairy and Bone Health
Heaney
J. Am. Coll. Nutr. 2009;28:82S-90S.
ABSTRACT | FULL TEXT  

Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial
Green et al.
Am J Clin Nutr 2007;85:460-464.
ABSTRACT | FULL TEXT  

The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease
Refsum et al.
J. Nutr. 2006;136:1731S-1740S.
ABSTRACT | FULL TEXT