 |
|
Vitamin K and the Prevention of Fractures
Systematic Review and Meta-analysis of Randomized Controlled Trials
Sarah Cockayne, MSc;
Joy Adamson, PhD;
Susan Lanham-New, PhD;
Martin J. Shearer, PhD, MRCPath;
Simon Gilbody, DPhil;
David J. Torgerson, PhD
Arch Intern Med. 2006;166:1256-1261.
Background Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture.
Objective To assess whether oral vitamin K (phytonadione and menaquinone) supplementation can reduce bone loss and prevent fractures.
Data Sources The search included the following electronic databases: MEDLINE (1966 to June 2005), EMBASE (1980 to June 2005), the Cochrane Library (issue 2, 2005), the ISI Web of Science (1945 to June 2005), the National Research Register (inception to the present), Current Controlled Trials, and the Medical Research Council Research Register.
Study Selection Randomized controlled trials that gave adult participants oral phytonadione and menaquinone supplements for longer than 6 months were included in this review.
Data Extraction Four authors extracted data on changes in bone density and type of fracture. All articles were double screened and double data extracted.
Data Synthesis Thirteen trials were identified with data on bone loss, and 7 reported fracture data. All studies but 1 showed an advantage of phytonadione and menaquinone in reducing bone loss. All 7 trials that reported fracture effects were Japanese and used menaquinone. Pooling the 7 trials with fracture data in a meta-analysis, we found an odds ratio (OR) favoring menaquinone of 0.40 (95% confidence interval [CI], 0.25-0.65) for vertebral fractures, an OR of 0.23 (95% CI, 0.12-0.47) for hip fractures, and an OR of 0.19 (95% CI, 0.11-0.35) for all nonvertebral fractures.
Conclusions This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.
Author Affiliations: York Trials Unit, Department of Health Sciences, University of York, York, England (Ms Cockayne and Drs Adamson, Lanham-New, Gilbody, and Torgerson); Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, England (Dr Lanham-New); and Vitamin K Laboratory, The Centre for Haemostasis and Thrombosis (The Haemophilia Reference Centre), St Thomas' Hospital, London, England (Dr Shearer).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED LETTERS
Possible Involvements of Vitamin K in Bone Quality
Toshihiro Sugiyama
Arch Intern Med. 2007;167(1):93-94.
EXTRACT
| FULL TEXT
Vitamin K and the Prevention of Fractures
Tsunenobu Tamura, Sarah L. Morgan, and Hidemi Takimoto
Arch Intern Med. 2007;167(1):94.
EXTRACT
| FULL TEXT
Risedronate for the Prevention of Hip Fractures: Concern About Validity of Trials
Jutta Martha Halbekath, Stefanie Schenk, Andreas von Maxen, Gabriele Meyer, and Ingrid Mühlhauser
Arch Intern Med. 2007;167(5):513-514.
EXTRACT
| FULL TEXT
Risedronate for the Prevention of Hip Fractures: Concern About Validity of Trials—Reply
Yoshihiro Sato
Arch Intern Med. 2007;167(5):514-515.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
McCann and Ames
Am. J. Clin. Nutr. 2009;90:889-907.
ABSTRACT
| FULL TEXT
Reporting of systematic reviews of micronutrients and health: a critical appraisal
Chung et al.
Am. J. Clin. Nutr. 2009;89:1099-1113.
ABSTRACT
| FULL TEXT
Dairy and Bone Health
Heaney
J. Am. Coll. Nutr. 2009;28:82S-90S.
ABSTRACT
| FULL TEXT
Prevalence of Low Bone Mass and Deficiencies of Vitamins D and K in Pediatric Patients With Cystic Fibrosis From 3 Canadian Centers
Grey et al.
Pediatrics 2008;122:1014-1020.
ABSTRACT
| FULL TEXT
Vitamin K in hand osteoarthritis: results from a randomised clinical trial
Neogi et al.
Ann Rheum Dis 2008;67:1570-1573.
ABSTRACT
| FULL TEXT
Vitamin K, circulating cytokines, and bone mineral density in older men and women
Shea et al.
Am. J. Clin. Nutr. 2008;88:356-363.
ABSTRACT
| FULL TEXT
Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms
Macdonald et al.
Am. J. Clin. Nutr. 2008;87:1513-1520.
ABSTRACT
| FULL TEXT
Effect of Vitamin K Supplementation on Bone Loss in Elderly Men and Women
Booth et al.
J. Clin. Endocrinol. Metab. 2008;93:1217-1223.
ABSTRACT
| FULL TEXT
Bone Health and Osteoporosis: The Role of Vitamin K and Potential Antagonism by Anticoagulants
Pearson
Nutr Clin Pract 2007;22:517-544.
ABSTRACT
| FULL TEXT
Dihydrophylloquinone intake is associated with low bone mineral density in men and women
Troy et al.
Am. J. Clin. Nutr. 2007;86:504-508.
ABSTRACT
| FULL TEXT
Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli
Sugiyama et al.
J Endocrinol 2007;194:213-222.
ABSTRACT
| FULL TEXT
Risedronate for the Prevention of Hip Fractures: Concern About Validity of Trials--Reply
Sato
Arch Intern Med 2007;167:514-515.
FULL TEXT
Risedronate for the Prevention of Hip Fractures: Concern About Validity of Trials
Halbekath et al.
Arch Intern Med 2007;167:513-514.
FULL TEXT
Possible Involvements of Vitamin K in Bone Quality
Sugiyama
Arch Intern Med 2007;167:93-94.
FULL TEXT
Vitamin K and the Prevention of Fractures
Tamura et al.
Arch Intern Med 2007;167:94-94.
FULL TEXT
Evidently...
Lehman
Evid. Based Med. 2006;11:136-136.
FULL TEXT
Other articles noted
Evid. Based Med. 2006;11:159-160.
FULL TEXT
|
