 |
|
Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation
Michael R. Irwin, MD;
Minge Wang, MSN;
Capella O. Campomayor, MS;
Alicia Collado-Hidalgo, PhD;
Steve Cole, PhD
Arch Intern Med. 2006;166:1756-1762.
Background Inflammation is associated with increased risk of cardiovascular disorders, arthritis, diabetes mellitus, and mortality. The effects of sleep loss on the cellular and genomic mechanisms that contribute to inflammatory cytokine activity are not known.
Methods In 30 healthy adults, monocyte intracellular proinflammatory cytokine production was repeatedly assessed during the day across 3 baseline periods and after partial sleep deprivation (awake from 11 PM to 3 AM). We analyzed the impact of sleep loss on transcription of proinflammatory cytokine genes and used DNA microarray analyses to characterize candidate transcription-control pathways that might mediate the effects of sleep loss on leukocyte gene expression.
Results In the morning after a night of sleep loss, monocyte production of interleukin 6 and tumor necrosis factor  was significantly greater compared with morning levels following uninterrupted sleep. In addition, sleep loss induced a more than 3-fold increase in transcription of interleukin 6 messenger RNA and a 2-fold increase in tumor necrosis factor messenger RNA. Bioinformatics analyses suggested that the inflammatory response was mediated by the nuclear factor  B inflammatory signaling system as well as through classic hormone and growth factor response pathways.
Conclusions Sleep loss induces a functional alteration of the monocyte proinflammatory cytokine response. A modest amount of sleep loss also alters molecular processes that drive cellular immune activation and induce inflammatory cytokines; mapping the dynamics of sleep loss on molecular signaling pathways has implications for understanding the role of sleep in altering immune cell physiologic characteristics. Interventions that target sleep might constitute new strategies to constrain inflammation with effects on inflammatory disease risk.
Author Affiliations: Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Sleep, sleep-disordered breathing and metabolic consequences
Levy et al.
Eur Respir J 2009;34:243-260.
ABSTRACT
| FULL TEXT
Metabolic aspects of obstructive sleep apnoea syndrome
Bonsignore and Eckel
ERR 2009;18:113-124.
ABSTRACT
| FULL TEXT
Sleep Habits and Susceptibility to the Common Cold
Cohen et al.
Arch Intern Med 2009;169:62-67.
ABSTRACT
| FULL TEXT
Sleep Disturbance and Depression Recurrence in Community-Dwelling Older Adults: A Prospective Study
Cho et al.
Am. J. Psychiatry 2008;165:1543-1550.
ABSTRACT
| FULL TEXT
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
Levy et al.
Eur Respir J 2008;32:1082-1095.
ABSTRACT
| FULL TEXT
Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer
Miller et al.
JCO 2008;26:971-982.
ABSTRACT
| FULL TEXT
Cross-sectional versus Prospective Associations of Sleep Duration with Changes in Relative Weight and Body Fat Distribution: The Whitehall II Study
Stranges et al.
Am J Epidemiol 2008;167:321-329.
ABSTRACT
| FULL TEXT
C-reactive protein Levels and Sleep Disturbances: Observations Based on The Northern Finland 1966 Birth Cohort Study
Liukkonen et al.
Psychosom. Med. 2007;69:756-761.
ABSTRACT
| FULL TEXT
Sleep Disturbances Increase Interleukin-6 Production During Pregnancy: Implications for Pregnancy Complications
Okun et al.
Reproductive Sciences 2007;14:560-567.
ABSTRACT
Sleep and health: everywhere and in both directions.
Zee and Turek
Arch Intern Med 2006;166:1686-1688.
FULL TEXT
|
