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Effectiveness and Cost-effectiveness of Thrombolysis in Submassive Pulmonary Embolism
Daniella J. Perlroth, MD;
Gillian D. Sanders, PhD;
Michael K. Gould, MD, MS
Arch Intern Med. 2007;167(1):74-80.
Background Thrombolytic therapy is controversial in patients with submassive pulmonary embolism.
Methods We performed a cost-effectiveness analysis to compare health effects and costs of treatment with alteplase plus heparin sodium vs heparin alone in hemodynamically stable patients with pulmonary embolism and right ventricular dysfunction by developing a Markov model and using data from clinical trials and administrative sources.
Results Based on data from a recent randomized trial, we assumed that the risk of clinical deterioration requiring treatment escalation was almost 3 times higher in patients who received heparin alone (23.2% vs 7.6%) but that the risk of death was equal in the 2 cohorts (2.7%). Based on registry data, we assumed that the risk of intracranial hemorrhage was approximately 3 times higher in patients who received alteplase plus heparin (1.2% vs 0.4%). Under these and other assumptions, thrombolysis resulted in marginally higher total lifetime health care costs ($43 900 vs $43 300) and was slightly less effective (10.52 vs 10.57 quality-adjusted life-years) than treatment with heparin alone. Thrombolysis was more effective and cost less than $50 000 per quality-adjusted life-year gained when we assumed that the baseline risk of death in the heparin group was 3 times the base-case value (8.1%) and that alteplase reduced the relative risk of death by at least 10%.
Conclusions Available data do not support the routine use of thrombolysis to treat patients with submassive pulmonary embolism. However, thrombolysis may prove to be cost-effective in selected subgroups of hemodynamically stable patients in whom the risk of death is higher.
Author Affiliations: Department of Medicine, School of Medicine, Stanford University, Stanford, Calif (Drs Perlroth and Gould); Department of Medicine and Duke Clinical Research Institute, Duke University, Durham, NC (Dr Sanders); and Medical Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif (Dr Gould).
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