 |
|
Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity
Evadnie Rampersaud, MSPH, PhD;
Braxton D. Mitchell, PhD;
Toni I. Pollin, PhD;
Mao Fu, PhD;
Haiqing Shen, PhD;
Jeffery R. O’Connell, PhD;
Julie L. Ducharme, MD;
Scott Hines, MD;
Paul Sack, MD;
Rosalie Naglieri, MD;
Alan R. Shuldiner, MD;
Soren Snitker, MD, PhD
Arch Intern Med. 2008;168(16):1791-1797.
Background Common FTO (fat mass and obesity associated) gene variants have recently been associated with body mass index (BMI) and obesity in several large studies. The role of lifestyle factors (such as physical activity) in those with an underlying FTO genetic predisposition is unknown.
Methods To determine if FTO variants are associated with BMI in Old Order Amish (OOA) individuals, and to further determine whether the detrimental associations of FTO gene variants can be lessened by increased physical activity, a total of 704 healthy OOA adults were selected from the Heredity and Phenotype Intervention (HAPI) Heart Study, an investigation of gene x environment interactions in cardiovascular disease, for whom objective quantified physical activity measurements were available and for whom 92 single-nucleotide polymorphisms (SNPs) in FTO were genotyped.
Results Twenty-six FTO SNPs were associated with BMI (P = .04 to <.001), including rs1477196 (P < .001) and rs1861868 (P < .001), 2 SNPs in moderate linkage disequilibrium in the OOA (D' = 0.82; r2 = 0.36). Stratified analyses of rs1861868 revealed its association with BMI to be restricted entirely to those subjects with low sex- and age-adjusted physical activity scores (P < .001); in contrast, the SNP had no effect on those with above-average physical activity scores (P = .29), with the genotype x physical activity interaction achieving statistical significance (P = .01). Similar evidence for interaction was also obtained for rs1477196.
Conclusions Our results strongly suggest that the increased risk of obesity owing to genetic susceptibility by FTO variants can be blunted through physical activity. These findings emphasize the important role of physical activity in public health efforts to combat obesity, particularly in genetically susceptible individuals.
Author Affiliations: Department of Medicine, University of Maryland (Drs Rampersaud, Mitchell, Pollin, Fu, Shen, O’Connell, Ducharme, Hines, Sack, Naglieri, Shuldiner, and Snitker), and the Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center (Dr Shuldiner), Baltimore. Dr Rampersaud is now with the Miller School of Medicine, Miami Institute for Human Genetics, University of Miami, Miami, Florida.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
In This Issue of Archives of Internal Medicine
Arch Intern Med. 2008;168(16):1730.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI
Corella et al.
J. Nutr. 2011;141:2219-2225.
ABSTRACT
| FULL TEXT
Do genetic variations alter the effects of exercise training on cardiovascular disease and can we identify the candidate variants now or in the future?
Hagberg
J. Appl. Physiol. 2011;111:916-928.
ABSTRACT
| FULL TEXT
Weight Loss and Low-Intensity Exercise for the Treatment of Metabolic Syndrome in Obese Postmenopausal Women
Joseph et al.
J Gerontol A Biol Sci Med Sci 2011;66A:1022-1029.
ABSTRACT
| FULL TEXT
Influence of Physical Inactivity on Associations Between Single Nucleotide Polymorphisms and Genetic Predisposition to Childhood Obesity
Xi et al.
Am J Epidemiol 2011;173:1256-1262.
ABSTRACT
| FULL TEXT
An Integrative Review of the Current Knowledge of Cardiovascular Disease and Associated Risk Factors in the Old Order Amish
Gillum and Staffileno
J Transcult Nurs 2011;22:182-190.
ABSTRACT
Association Between Short Sleep Duration and Obesity Among South Korean Adolescents
Park
West J Nurs Res 2011;33:207-223.
ABSTRACT
Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women
Ahmad et al.
Diabetes Care 2011;34:675-680.
ABSTRACT
| FULL TEXT
Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics
Stranger et al.
Genetics 2011;187:367-383.
ABSTRACT
| FULL TEXT
Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence: Influence of Loci Identified by Genome-Wide Association Studies
den Hoed et al.
Diabetes 2010;59:2980-2988.
ABSTRACT
| FULL TEXT
Life-Course Analysis of a Fat Mass and Obesity-Associated (FTO) Gene Variant and Body Mass Index in the Northern Finland Birth Cohort 1966 Using Structural Equation Modeling
Kaakinen et al.
Am J Epidemiol 2010;172:653-665.
ABSTRACT
| FULL TEXT
From the Cover: A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
Ho et al.
Proc. Natl. Acad. Sci. USA 2010;107:8404-8409.
ABSTRACT
| FULL TEXT
Attenuation of the Effect of the FTO rs9939609 Polymorphism on Total and Central Body Fat by Physical Activity in Adolescents: The HELENA Study
Ruiz et al.
Arch Pediatr Adolesc Med 2010;164:328-333.
ABSTRACT
| FULL TEXT
Life course variations in the associations between FTO and MC4R gene variants and body size
Hardy et al.
Hum Mol Genet 2010;19:545-552.
ABSTRACT
| FULL TEXT
Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study
Liem et al.
Am J Clin Nutr 2010;91:321-328.
ABSTRACT
| FULL TEXT
The FTO gene rs9939609 obesity-risk allele and loss of control over eating
Tanofsky-Kraff et al.
Am J Clin Nutr 2009;90:1483-1488.
ABSTRACT
| FULL TEXT
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
Sonestedt et al.
Am J Clin Nutr 2009;90:1418-1425.
ABSTRACT
| FULL TEXT
Modification effects of physical activity and protein intake on heritability of body size and composition
Silventoinen et al.
Am J Clin Nutr 2009;90:1096-1103.
ABSTRACT
| FULL TEXT
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
Vimaleswaran et al.
Am J Clin Nutr 2009;90:425-428.
ABSTRACT
| FULL TEXT
Childhood obesity: are genetic differences involved?
Bouchard
Am J Clin Nutr 2009;89:1494S-1501S.
ABSTRACT
| FULL TEXT
FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity
Hakanen et al.
J. Clin. Endocrinol. Metab. 2009;94:1281-1287.
ABSTRACT
| FULL TEXT
|
