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  Vol. 168 No. 2, January 28, 2008 TABLE OF CONTENTS
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Association of Exercise Capacity on Treadmill With Future Cardiac Events in Patients Referred for Exercise Testing

Pamela N. Peterson, MD, MSPH; David J. Magid, MD, MPH; Colleen Ross, MS; P. Michael Ho, MD, PhD; John S. Rumsfeld, MD, PhD; Michael S. Lauer, MD; Ella E. Lyons, MS; Scott S. Smith, MD; Frederick A. Masoudi, MD, MSPH

Arch Intern Med. 2008;168(2):174-179.

Background  Little is known about the association between exercise capacity and nonfatal cardiac events in patients referred for exercise treadmill testing (ETT). Our objective was to determine the prognostic importance of exercise capacity for nonfatal cardiac events in a clinical population.

Methods  A cohort study was performed of 9191 patients referred for ETT. Median follow-up was 2.7 years. Exercise capacity was quantified as the proportion of age- and sex-predicted metabolic equivalents achieved and categorized as less than 85%, 85% to 100%, and greater than 100%. Individual primary outcomes were myocardial infarction, unstable angina, and coronary revascularization. All-cause mortality was a secondary outcome.

Results  Patients with lower exercise capacity were more likely to be female (55.38% vs 42.62%); to have comorbidities such as diabetes (23.16% vs 9.61%) and hypertension (59.43% vs 44.05%); and to have abnormal ETT findings such as chest pain on the treadmill (12.09% vs 7.63%), abnormal heart rate recovery (82.74% vs 64.13%), and abnormal chronotropic index (32.89% vs 12.20%). In multivariable analysis, including other ETT variables, lower exercise capacity (< 85% of predicted) was associated with increased risk of myocardial infarction (hazard ratio [HR], 2.36; 95% confidence interval [CI], 1.55-3.60), unstable angina (HR, 2.39; 95% CI, 1.78-3.21), coronary revascularization (HR, 1.75; 95% CI, 1.46- 2.08), and all-cause mortality (HR, 2.90; 95% CI, 1.88-4.47) compared with exercise capacity greater than 100% of predicted.

Conclusion  Adjusting for patient characteristics and other ETT variables, reduced exercise capacity was associated with both nonfatal cardiovascular events and mortality in patients referred for ETT.


Author Affiliations: Division of Cardiology, Department of Medicine, Denver Health Medical Center, Denver, Colorado (Drs Peterson and Masoudi); Division of Cardiology, Department of Medicine, University of Colorado at Denver and Health Sciences Center (Drs Peterson, Ho, Rumsfeld, and Masoudi); Clinical Research Unit (Drs Peterson, Magid, Ho, Rumsfeld, and Masoudi and Mss Ross and Lyons) and Department of Internal Medicine (Dr Smith), Kaiser Permanente of Colorado, Denver; Division of Cardiology, Department of Medicine, Denver Veterans Affairs Medical Center (Drs Ho and Rumsfeld); and Cleveland Clinic Foundation, Cleveland, Ohio (Dr Lauer).



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RELATED LETTERS

The Hurdles of Translating a Single-Center Observation Into Practice
Luca Testa, Ravinay Bhindi, and Adrian Banning
Arch Intern Med. 2008;168(15):1719-1720.
EXTRACT | FULL TEXT  

The Hurdles of Translating a Single-Center Observation Into Practice—Reply
Pamela N. Peterson and Frederick A. Masoudi
Arch Intern Med. 2008;168(15):1720.
EXTRACT | FULL TEXT  


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