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Guideline-Concordant Therapy and Reduced Mortality and Length of Stay in Adults With Community-Acquired PneumoniaPlaying by the Rules
Caitlin McCabe, BSc;
Cheryl Kirchner, RN, BSN, MS;
Huiling Zhang, MD, MPH, MBA;
Jennifer Daley, MD, MPH;
David N. Fisman, MD, MPH, FRCPC
Arch Intern Med. 2009;169(16):1525-1531.
Background Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. Clinical practice guidelines for empirical CAP treatment, formulated jointly by the Infectious Diseases Society of America (IDSA) and American Thoracic Society (ATS), remain controversial and inconsistently applied. We evaluated the impact of guideline-concordant therapy on in-hospital survival and other outcomes using a large database including adults treated for CAP in both community and tertiary care hospitals.
Methods We evaluated the association between in-hospital survival and guideline-concordant therapy using logistic regression models. Time until discharge from hospital and discontinuation of parenteral therapy were evaluated using survival analysis.
Results Of 54 619 non–intensive care unit inpatients with CAP hospitalized at 113 community hospitals and tertiary care centers, 35 477 (65%) received initial guideline-concordant therapy. After adjustment for severity of illness and other confounders, guideline-concordant therapy was associated with decreased in-hospital mortality (odds ratio [OR], 0.70; 95% confidence interval [CI], 0.63-0.77), sepsis (OR, 0.83; 95% CI, 0.72-0.96), and renal failure (OR, 0.79; 95% CI, 0.67-0.94), and reduced both length of stay and duration of parenteral therapy by approximately 0.6 days (P < .001 for both comparisons). These findings were robust with alternate definitions of "concordance" and were linked to treatment with fluoroquinolone or macrolide agents.
Conclusions Guideline-concordant therapy for CAP is associated with improved health outcomes and diminished resource use in adults. The mechanisms underlying this finding remain speculative and warrant further study, but our findings nonetheless support compliance with CAP clinical practice guidelines as a benchmark of quality of care.
Author Affiliations: Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada (Ms McCabe and Dr Fisman); Division of Clinical Quality, Tenet Healthcare, Dallas, Texas (Ms Kirchner and Dr Zhang); Partners Community Healthcare Inc and the Institute of Health Policy, Massachusetts General Hospital and Partners Healthcare, Harvard Medical School, Boston (Dr Daley); and Department of Epidemiology, Dalla Lana School of Public Health, and Department of Health Policy, Management, and Evaluation, University of Toronto, and Ontario Agency for Health Protection and Promotion, Toronto (Dr Fisman).
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