 |
|
A Randomized Study on the Effect of Weight Loss on Obstructive Sleep Apnea Among Obese Patients With Type 2 DiabetesThe Sleep AHEAD Study
Gary D. Foster, PhD;
Kelley E. Borradaile, PhD;
Mark H. Sanders, MD;
Richard Millman, MD;
Gary Zammit, PhD;
Anne B. Newman, MD;
Thomas A. Wadden, PhD;
David Kelley, MD;
Rena R. Wing, PhD;
F. Xavier Pi-Sunyer, MD;
David Reboussin, PhD;
Samuel T. Kuna, MD; for the Sleep AHEAD Research Group of the Look AHEAD Research Group
Arch Intern Med. 2009;169(17):1619-1626.
Background The belief that weight loss improves obstructive sleep apnea (OSA) has limited empirical support. The purpose of this 4-center study was to assess the effects of weight loss on OSA over a 1-year period.
Methods The study included 264 participants with type 2 diabetes and a mean (SD) age of 61.2 (6.5) years, weight of 102.4 (18.3) kg, body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) of 36.7 (5.7), and an apnea-hypopnea index (AHI) of 23.2 (16.5) events per hour. The participants were randomly assigned to either a behavioral weight loss program developed specifically for obese patients with type 2 diabetes (intensive lifestyle intervention [ILI]) or 3 group sessions related to effective diabetes management (diabetes support and education [DSE]).
Results The ILI participants lost more weight at 1 year than did DSE participants (10.8 kg vs 0.6 kg; P < .001). Relative to the DSE group, the ILI intervention was associated with an adjusted (SE) decrease in AHI of 9.7 (2.0) events per hour (P < .001). At 1 year, more than 3 times as many participants in the ILI group than in the DSE group had total remission of their OSA, and the prevalence of severe OSA among ILI participants was half that of the DSE group. Initial AHI and weight loss were the strongest predictors of changes in AHI at 1 year (P < .01). Participants with a weight loss of 10 kg or more had the greatest reductions in AHI.
Conclusions Physicians and their patients can expect that weight loss will result in significant and clinically relevant improvements in OSA among obese patients with type 2 diabetes.
Trial Registration clinicaltrials.gov Identifier: NCT00194259
Author Affiliations: Center for Obesity Research and Education, Temple University, Philadelphia, Pennsylvania (Drs Foster and Borradaile); Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine (Dr Sanders) (retired), Department of Epidemiology, Graduate School of Public Health (Dr Newman), and Department of Medicine (Dr Kelley), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Medicine, Alpert Medical School (Dr Millman), and Weight Control and Diabetes Research Center (Dr Wing), Brown University, Providence, Rhode Island; Clinilabs Sleep Disorder Institute, Columbia University College of Physicians and Surgeons, New York, New York (Dr Zammit); Center for Weight and Eating Disorders (Dr Wadden) and Department of Medicine (Dr Kuna), University of Pennsylvania, Philadelphia; Obesity Research Center, St Luke’s–Roosevelt Hospital, Columbia University, New York, New York (Dr Pi-Sunyer); and Division of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina (Dr Reboussin).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED ARTICLE
In This Issue of Archives of Internal Medicine
Arch Intern Med. 2009;169(17):1550.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Effect of Weight Loss on Obstructive Sleep Apnea in People with Type 2 Diabetes
JWatch General 2009;2009:2-2.
FULL TEXT
All you need to read in the other general journals
BMJ 2009;339:b4054-b4054.
FULL TEXT
|
