This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurology  • Stroke  • Cardiovascular System  • Review  • Cardiovascular Disease/ Myocardial Infarction  • Drug Therapy, Other  • Hypertension  • Alert me on articles by topic  Social Bookmarking   What's this?

Marvin Moser, MD; Peter U. Feig, MD

Arch Intern Med. 2009;169(20):1851-1856.

Background  The use of thiazide diuretics has decreased over the past 30 years despite data from many well-controlled clinical trials demonstrating that the use of these agents as monotherapy or in combination with other antihypertensive agents will reduce blood pressure and decrease cardiovascular as well as cerebrovascular events.

Methods  We reviewed clinical and experimental data on thiazide diuretics since their introduction in the late 1950s.

Results  The results of thiazide-based therapy in young and old are consistently positive despite concerns about some metabolic changes, eg, insulin resistance or hypokalemia, that may occur.

Conclusion  We conclude that these agents are safe, effective, and well tolerated and should continue to be used either as monotherapy or with other medications in the management of hypertension.

Author Afffiliations: Department of Medicine (Cardiology), Yale University School of Medicine, New Haven, Connecticut (Dr Moser); Merck Research Laboratories, Rahway, New Jersey (Dr Feig); and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York (Dr Feig).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?