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Laura Coudrey, MD

Arch Intern Med. 1998;158:1173-1180.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

New cardiac-specific markers have recently been introduced into the arena of cardiac diagnostic tests. The cardiac troponins, because of their extraordinary high specificity for myocardial cell injury, have gained particular interest. They can be used in a variety of clinical situations, including differentiation of skeletal from cardiac muscle injury; detection of minor myocardial cell damage in coronary insufficiency syndromes, which allows stratification of patients into high- and low-risk categories; detection of perioperative myocardial infarction; estimation of infarct size; and assessment of therapeutic success of reperfusion therapy. The application of the troponin proteins in relation to percutaneous transluminal coronary angioplasty and in the diagnosis of acute myocarditis has also been recently described.

BIOCHEMICAL MAKEUP

The troponins are 3 distinct proteins (I, C, and T) that are expressed in cardiac and skeletal muscle and are encoded for by different genes. These molecules form a complex that regulates the calcium-dependent interaction of . . . [Full Text of this Article]

IMMUNOASSAYS

DIAGNOSIS WHEN SKELETAL MUSCLE INJURY IS PRESENT

DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION

DETECTION OF REPERFUSION

ESTIMATION OF INFARCT SIZE

RISK STRATIFICATION

DETECTING PERIOPERATIVE MYOCARDIAL INFARCTIONS

APPLICATION IN CORONARY ANGIOPLASTY

DIAGNOSIS IN MYOCARDITIS

CONCLUSIONS

From the Cardiology Division, State University of New York at Stony Brook.

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