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It is still common practice to use thyroid suppression in the management of thyroid nodules.¹ This method is intended to shrink existing nodules, which is considered to be a favorable sign, indicating that the nodules are benign and therefore do not require surgery. Is this use of thyroid suppression a viable method of managing thyroid nodules? Or is it time for us to abandon this practice completely?

How effective is this therapy? Most nodules do not decrease in size during suppressive therapy. In my opinion, the only nodules that significantly decrease in size or disappear altogether would have done so even without the use of thyroid suppression. This is because the nodules that either resolve or decrease do so based on the processes of underlying diseases, such as hemorrhage (which tends to resolve), localized thyroiditis (usually Hashimoto), spontaneous degeneration, or necrosis of the nodule.

Is the use of thyroid suppression . . . [Full Text of this Article]