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Thinking Inside Out

Arch Intern Med. 1998;158:1964.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

VENOUS THROMBOEMBOLIC disease (VTE) is recognized as a significant cause of morbidity and mortality with an incidence of more than 500000 cases per year.¹ Patients affected represent many different risk groups in a variety of clinical settings. The diagnosis of deep venous thrombosis (DVT) is at times clinically challenging, with as many as 75% of patients suspected of having VTE lacking objective evidence of thrombosis. Furthermore, up to 50% of patients with thrombosis may be asymptomatic and never receive a diagnosis.² Heparin has been the mainstay of therapy for documented VTE since the 1960s. Between the 1960s and the 1990s, advances in the treatment of VTE were limited to the transition from bolus to continuous intravenous infusion of heparin and the evolution of dosing nomograms.³ The development of low-molecular-weight (LMW) heparin has led to a reevaluation of the standard treatment of VTE.

Heparin administration in the treatment of VTE prevents . . . [Full Text of this Article]

Richard S. Liebowitz, MD
Department of Internal Medicine
Arizona Health Sciences Center
1501 N Campbell Ave
Tucson, AZ 85724

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Outpatient Protocols for Treatment of Venous Thromboembolism Using Low-Molecular-Weight Heparin: To Treat or Not to Treat at Home
Alex C. Spyropoulos, Linda Harrison, and Richard S. Liebowitz
Arch Intern Med. 1999;159(10):1139-1140.
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Arch Intern Med. 1998;158(18):2001-2003.
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