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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In the July 14, 1997, issue of the ARCHIVES, Joshi and Miller,¹ in their review article on doxycycline, state, "Doxycycline, like any tetracycline, may cause photosensitivity reactions." The Table on page 1422 reports an equal rate of photosensitivity for tetracycline and doxycycline. However, Cunha,^2-3 in 2 recent articles about doxycycline, states that "doxycycline does not cause the photosensitizing reaction that may occur with conventional tetracycline"² and that "photosensitizing reactions, while common with tetracyclines, are rare with doxycycline."³ I would appreciate an explanation of this discrepancy.

Arthur Krulewitz, MD
Granby, Mass

1. Joshi N, Miller DQ. Doxycycline revisited. Arch Intern Med. 1997;157:1421-1428. FREE FULL TEXT 2. Cunha B. New uses for older antibiotics. Postgrad Med J. 1997;101:68-86. PUBMED 3. Cunha B. Doxycycline revisited. Intern Med. May 1997:65-72.

In reply

In response to Krulewitz' comments: Doxycycline is well described to cause photosensitivity reactions.^1-2 Although several literature sources report a low incidence of this adverse effect, to our knowledge careful direct comparisons between conventional tetracyclines and doxycycline are not available. The package insert of doxycycline preparations continues to warn of photosensitivity as a potential adverse effect of tetracyclines as . . . [Full Text of this Article]

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Doxycycline Revisited
Nirmal Joshi and Debra Q. Miller
Arch Intern Med. 1997;157(13):1421-1428.
ABSTRACT