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Henoch-Schönlein Purpura Induced by Losartan Therapy
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Losartan potassium is an orally active, nonpeptide angiotensin II type 1 receptor antagonist that has recently been approved for the treatment of hypertension in many countries.1 Its adverse effects include dizziness, headache, hypotension, renal dysfunction, and hyperkalemia. Uncommon serious adverse events include stroke, worsening heart failure, unstable angina, and myocardial infarction.1-3
We describe a 62-year-old man who developed Henoch-Schönlein purpura while taking losartan. In October 1996, he was admitted with a 1-week history of palpable purpura of the lower limbs, polyarthralgias, and pedal edema. He had been healthy until 3 months before admission when enalapril maleate, 10 mg/d, was prescribed for moderate hypertension. Two weeks before admission enalapril therapy was stopped because of a persistent cough attributed to the use of this drug, and losartan potassium, 50 mg/d, was given instead. Other medications were not administered. A skin biopsy specimen revealed leukocytoclastic vasculitis with IgA deposition along dermal vessel walls. . . . [Full Text of this Article]
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