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We report a case of an anticonvulsant hypersensitivity syndrome in a 55-year-old white man who presented with a pruritic maculopapular rash, fever, hepatitis, and eosinophilia (13%). The episode was complicated by anterior uveitis, a feature until now not recognized as a manifestation of hypersensitivity to the use of anticonvulsants. He suffered from recent onset of a complex partial seizure with secondary generalization. After neurologic workup, the patient began treatment with carbamazepine. He was healthy until 7 weeks after the start of treatment, when he developed an itching rash of the lower extremities. The treatment was changed to valproic acid.

During the following 5 days, fever (body temperature, 39.5°C) developed and the patient was referred to the internal medicine clinic. He was anicteric and had a persisting pruritic rash, mostly of the lower limbs, the ventral trunk, and the dorsal part of the hands. Oral enanthema with labial aphthous lesions were . . . [Full Text of this Article]

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Anticonvulsant Hypersensitivity Syndrome
Carmela C. Vittorio and Jennie J. Muglia
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ABSTRACT