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Since its introduction, ketorolac tromethamine (Toradol, Wyeth Laboratories Inc, Philadelphia, Pa) has been extensively used as a potent nonsteroidal anti-inflammatory, analgesic, and antipyretic drug. Pancreatitis is not a recognized complication of the use of ketorolac tromethamine, our MEDLINE search revealing no case reports of acute pancreatitis attributed to the use of ketorolac tromethamine. We describe a middle-aged woman who developed acute pancreatitis after administration of parenteral ketorolac tromethamine.

A 44-year-old woman with a history of seizure disorder and postthyroidectomy hypothyroidism was seen in the emergency department for left precordial pleuritic-type chest pain. She had no history of peptic ulcer disease or gallstones and denied smoking, alcohol abuse, or the use of illicit drugs. Current medications included carbamazepine, levothyroxine sodium, and conjugated estrogen.

Her vital signs were normal and results of a physical examination were unremarkable. Serum electrolyte levels, complete blood cell count, and levels of amylase and lipase were normal . . . [Full Text of this Article]