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The review article on doxycycline by Joshi and Miller¹ was not only interesting but also valuable—particularly in this time of managed care and cost containment. Doxycycline is an effective and well-studied drug that is now quite cost competitive—although I still remember when it was first released more than 20 years ago at the extraordinary cost of $1 per capsule.

In reviewing doxycycline, one should also address its pharmacokinetics. Doxycycline has a half-life of 15 to 22 hours.² This means that it should be easy to maintain effective levels of the drug for a day or more after its administration. Since it absorbs well, 1 daily dose of doxycycline seems reasonable. If it is administered in the usual dosage of 100 mg twice daily, the serum concentration does not reach a steady state for days.

A loading dose of doxycycline should also be considered because the drug is well tolerated and . . . [Full Text of this Article]

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