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A new pattern of Pseudomonas aeruginosa infection in patients with advanced human immunodeficiency virus infection has emerged in recent years. It is characterized by relapsing episodes of community-acquired bronchopulmonary infection, most of them without radiological evidence of pneumonia, a low mortality rate, or other risk factors for P aeruginosa infection.^1-2 Eradication of the bacteria in these patients has been virtually impossible despite repeated courses of adequate antibiotic therapy in most of them, while prevention of relapses with the use of inhaled aminoglycosides has proven successful only in anecdotal reports.^3-4 We recently treated 2 patients with relapsing bronchopulmonary P aeruginosa infection who ceased to experience relapse after triple antiretroviral therapy was started.

The patients were a 36-year-old man and a 35-year-old woman, both of whom had been diagnosed as having acquired immunodeficiency syndrome more than 4 years ago. Both had had 2 episodes of Pneumocystis carinii pneumonia, and 2 and 1 . . . [Full Text of this Article]