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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

I read with interest the meta-analysis of zinc salts lozenges for treatment of the common cold by Jackson et al.¹ Six of the 8 studies published were included in this meta-analysis. Two studies using viral inoculation of volunteers were excluded because of their different designs. The virus challenge model has certain advantages over the natural cold model, which makes it an acceptable method of investigating effectiveness of various remedies for the common cold.² The authors assigned an odds ratio (OR) of 1.0 for these studies; using the duration of viral shedding as a surrogate marker for duration of symptoms, they produced a subsequent summary OR of 0.57 for the presence of any cold symptoms at 7 days. It is expected that viral shedding might persist after resolution of symptoms, so this OR is overestimated.

The authors found that analysis after excluding a trial using an inadequate zinc gluconate dose³ produced . . . [Full Text of this Article]

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RELATED ARTICLE

A Meta-analysis of Zinc Salts Lozenges and the Common Cold
Jeffrey L. Jackson, Cecily Peterson, and Emil Lesho
Arch Intern Med. 1997;157(20):2373-2376.
ABSTRACT