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Carnitine Stands on Its Own in HIV Infection Treatment
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We read with great interest the recent article by Fairfield and colleagues.1 We agree with their conclusions that appropriate investigations are necessary to establish with confidence the benefit or risk associated with the use of complementary and alternative medicine by persons infected with the human immunodeficiency virus (HIV). However, our experience is that the investigation of unconventional therapies is regarded as trivial by most researchers and, consequently, high-quality scientific evidence that clearly establishes the effectiveness (or lack thereof) of these interventions is lacking.
We have focused our recent research on the use of carnitines by HIV-infected individuals on the observation that most of them attending our clinic as outpatients received L-carnitine supplementation, anecdotally reporting an improved sense of well-being and a general improvement of physical conditions.
Deficiency of carnitines is common in individuals infected with HIV2-3 and appears to contribute to the mitochondrial toxicity of nucleoside analogs.4-6 However, even though . . . [Full Text of this Article]
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Patterns of Use, Expenditures, and Perceived Efficacy of Complementary and Alternative Therapies in HIV-Infected Patients
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Arch Intern Med. 1998;158(20):2257-2264.
ABSTRACT
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