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The benefits of highly active antiretroviral therapy (HAART) on morbidity and mortality related to the human immunodeficiency virus (HIV) may dampen due to the emergence of drug resistance.¹ Resistance secondary to poor adherence is one of the main reasons for drug failure. Developing tools to aptly monitor adherence to HAART regimens may be especially useful to identify patients at high risk for nonadherence. These patients may benefit from an intensification of the interventions to reinforce compliance.

We designed a cross-sectional study to detect key variables in adherence to HAART. One hundred unselected patients with HIV in a general hospital during April 1998 were interviewed by a psychologist trained in adherence. They were asked about the number of pills skipped during the last month. Patients were also asked about variables related to adherence (Table 1) and completed the Profile of Mood States questionnaire.² The percentage of adherence was calculated . . . [Full Text of this Article]

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