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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We report 2 cases of pulmonary edema associated with the use of troglitazone (Rezulin; Parke-Davis, Morris Plains, NJ).

Report of a Case.

Case 1.

A 65-year-old woman with type 2 diabetes began troglitazone therapy. Her hemoglobin A_1c fraction improved from 0.10 to 0.06. After 8 months of therapy, she reported lower-extremity edema, which became severe. The findings of her physical examination were otherwise unremarkable, and there was no proteinuria. Furosemide therapy was initiated, but the edema progressed. After 13 months, she had shortness of breath and orthopnea. Details are noted in Table 1. A chest x-ray film showed pulmonary edema. An electrocardiogram and an adenosine stress test with a tetrofosmin perfusion scan revealed no abnormalities. A gated blood pool sample showed an ejection fraction of 0.62, with a normal left ventricle. After the troglitazone therapy was discontinued, the patient's fluid overload improved, and she lost 7.1 kg after 3 weeks.

Table appears in full text version. Clinical Characteristics of 2 Cases . . . [Full Text of this Article]

Case 2.

Comment.
Irl B. Hirsch, MD; Janet Kelly, PharmD; Stephanie Cooper, MD
Seattle, Wash

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