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Toxic epidermal necrolysis (TEN) is a devastating full-thickness epidermal exfoliative disease caused by an inciting medication.¹ Clinical evidence of the disease usually presents 1 to 2 weeks after administration of the inciting medication. However, upon reexposure to a medication that previously caused TEN or exposure to a structurally related compound, the subsequent reaction is fulminant, is more severe, and may occur after the first dose.² Although TEN has been documented after exposure to quinolones, the incidence is very low.³

Report of a Case

A 52-year-old woman presented with the complaint of erythematous rash. The patient had taken only 1 dose (100 mg) of trovafloxacin (Trovan; Pfizer Inc, New York, NY) for sinusitis 24 hours prior to the development of symptoms. At the time of her admission, she was noted to have a diffuse, erythematous rash, scattered bullae, and large areas of desquamation involving the chest, abdomen, and extremities. Findings in skin biopsy specimens obtained . . . [Full Text of this Article]

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