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A Continuing Concern

Arch Intern Med. 1999;159:2259-2260.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN 1995, the Cardiorenal Advisory Committee of the Food and Drug Administration, after a lengthy deliberation, unanimously decided that sublingual nifedipine should not officially be approved for the treatment of hypertensive emergencies. Despite this decision and despite authoritative voices^1-4 warning against this practice, the use of short-acting nifedipine for what was perceived as hypertensive emergencies remained widespread in the United States and all over the globe.

Until recently, this intervention was used routinely in emergency departments, in nursing homes, and on hospital wards, where it often was given as a standing order, particularly in postoperative patients. In 1996, we and our colleagues⁵ published a review article on the putative dangers of sublingual nifedipine in hypertensive emergencies. Interestingly, short-acting nifedipine has never been approved for the treatment of any form of hypertension, emergent or not, and the safety and efficacy of this intervention remain to be determined. In view of the . . . [Full Text of this Article]

Franz H. Messerli, MD
Department of Internal Medicine
Section on Hypertensive Diseases
Ochsner Clinic
1514 Jefferson Hwy
New Orleans, LA 70121

Ehud Grossman, MD
Tel-Hashomer, Israel

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