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Investigations of Possible Failures of Postexposure Prophylaxis Following Occupational Exposures to Human Immunodeficiency Virus
Elise M. Jochimsen, MD;
Chi-Cheng Luo, PhD;
John F. Beltrami, MD;
Richard A. Respess, PhD;
Charles A. Schable, MS;
Denise M. Cardo, MD
Arch Intern Med. 1999;159:2361-2363.
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INTRODUCTION
Information suggesting that zidovudine postexposure prophylaxis (PEP) reduces the risk of human immunodeficiency virus (HIV) transmission after occupational exposure to HIV-infected blood prompted the US Public Health Service to provide guidelines for the use of combination drug therapy for chemoprophylaxis after certain occupational exposures to HIV.1-2 Many health care workers (HCWs) worldwide may take PEP following occupational exposures to HIV.
Although evidence suggests that PEP may be effective,3 failures of PEP with zidovudine have been reported.4-5 It is likely that failures of PEP with combination therapy also will occur, and one possible case has recently been described.6 Since little is known about the effectiveness of PEP for occupational HIV exposures, investigation of cases of possible PEP failure can provide important information about factors that may influence PEP . . . [Full Text of this Article]
REPORT OF CASES
CASE 1 CASE 2
COMMENT
From the HIV Infections Branch, Hospital Infections Program (Drs Jochimsen and Cardo) and Division of AIDS, STD, and TB Laboratory Research (Drs Luo and Respess and Mr Schable), National Center for Infectious Diseases, Centers for Disease Control and Prevention, and Georgia Department of Human Resources (Dr Beltrami), Atlanta.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Postexposure Prophylaxis in Children and Adolescents for Nonoccupational Exposure to Human Immunodeficiency Virus
Havens and Committee on Pediatric AIDS
Pediatrics 2003;111:1475-1489.
ABSTRACT
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