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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with great interest the study by van der Klauw et al¹ of drug-associated agranulocytosis in a Dutch hospital. We agree with their conclusions (the highest risks of drug-induced agranulocytosis occur with thyroid inhibitors, the combination drug sulfamethoxazole-trimethoprim, sulfasalazine, clomipramine hydrochloride, and dipyrone combined with analgesics) and want to give some data from our own experience.²

Fifty-eight episodes of drug-induced agranulocytosis (neutrophil count, <0.5x10⁹/L; all patients fulfilled the criteria of Benichou and Solal-Celignoy³) were treated at Strasbourg Teaching Hospital, Strasbourg, France, between January 1985 and January 1997. The mean age of the patients was 65.7 years, and the female-male ratio was 1:4. During hospitalization, all patients had at least 1 of the following manifestations: isolated fever and chills (17/58 [31%]), sore throat (13/58 [22.4% ]), septicemia (12/58 [21%]), pneumonia (11/58 [14%]), or other localized infections (7/58 [11.6%]). The mean neutrophil count was 0.09x10⁹. . . [Full Text of this Article]

Andrès Emmanuel, MD; Frédéric Maloisel, MD
Strasbourg, France

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