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  Vol. 159 No. 21, November 22, 1999 TABLE OF CONTENTS
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Hyperresponsiveness of Arginine Vasopressin to Metoclopramide in Patients With Pheochromocytoma

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The administration of metoclopramide hydrochloride is commonly used as a provocative test in the screening of patients with pheochromocytoma because it produces a severe pressor reaction in these patients.1 This phenomenon has been attributed to catecholamine-releasing effects of the antidopaminergic agent.1 However, a dissociation between blood pressure (BP) and plasma catecholamines has occurred in patients with pheochromocytoma,2 suggesting that other endocrine factors may play a role in the control of BP in these patients. Specifically, the pressor response during stimulation with metoclopramide might be mediated at least in part by enhanced circulating levels of vasopressin; the stimulatory effect of metoclopramide on vasopressin secretion is well known.3 To verify this possibility, we have evaluated the arginine vasopressin (AVP) secretory pattern in 3 patients affected by pheochromocytoma during stimulation with metoclopramide.

Report of Cases

Case 1

A 47-year-old woman was admitted to the hospital with crises of hypertension (BP, 190/110 mm Hg), tachycardia (heart rate, 110 beats/min), . . . [Full Text of this Article]

Case 2

Case 3


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