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Warfarin vs Aspirin and AFASAK 2
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In a recent issue of the Archives, one notes how the article on the Second Copenhagen Atrial Fibrillation, Aspirin, and Anticoagulation Study (AFASAK 2) by Gulløv et al1 and Albers'2 editorial conceal the most striking data from AFASAK 2, namely, that warfarin was not statistically significantly superior to aspirin alone for stroke prevention in atrial fibrillation. The cumulative primary event rates were 3.6% with aspirin and 2.8% with adjusted-dose warfarin sodium (P=.67). The introductory dependent clause in the "Conclusions" section of the Gulløv et al abstract "Although the difference was insignificant . . ." perhaps should be gist of the final conclusion vis-à-vis AFASAK 2's aspirin vs warfarin. The abstract's "Conclusions" section, however, cloaks the data regarding warfarin vs aspirin alone. No mention at all is made of the above findings. Albers' editorial likewise footnotes his position with no mention, for example, of another important recent meta-analysis about . . . [Full Text of this Article]
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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State-of-the-Art Review: Warfarin Therapy: A Review of the Literature Since the Fifth American College of Chest Physicians' Consensus Conference on Antithrombotic Therapy
Lodwick
CLIN APPL THROMB HEMOST 1999;5:208-215.
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