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Moris and Garcia-Monco¹ recently presented an excellent review on drug-induced aseptic meningitis in the ARCHIVES. As they pointed out, the pathogenesis of the reaction is unknown. We have recently published a report on a series of 12 patients with a history of trimethoprim-induced systemic adverse reactions closely resembling aseptic meningitis.² Among that group, treatment with trimethoprim in vitro induced substantial interleukin 6 (IL-6) production, but no IL-1, tumor necrosis factor (TNF-), or IL-2 in the purified peripheral blood mononuclear cells. In support of those findings, we report a case of a trimethoprim-induced aseptic meningitis-like reaction, in which cytokines from blood and cerebrospinal fluid (CSF) were measured.

Report of a Case

A 30-year-old healthy man with no known allergies had symptoms similar to those of a prolonged mild upper respiratory infection (no fever). Maxillary sinusitis was suspected by his primary health care physician, and he was given a twice-daily combination of trimethoprim (160 mg) . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Trimethoprim-Induced Aseptic Meningitis in an Adolescent Male
Redman et al.
Pediatrics 2002;110:e26-26.
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