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Massive pulmonary bleeding due to invasive aspergillosis is often a fatal complication in patients with acute leukemia.¹ We describe successful treatment with recombinant factor VIIa (rFVIIa) (Novoseven; Novo Nordisk, Copenhagen, Denmark) in a patient with this condition.

Report of a Case

A 49-year-old man developed unexplained fever while he was severely neutropenic (0.003 x 10⁹/L) after induction chemotherapy for acute lymphoblastic leukemia (Figure 1). The fever did not respond to antibiotic treatment. Because chest radiograph findings then showed a small pulmonary infiltrate in the left lower lobe, bronchoalveolar lavage was performed. An infectious agent could not be demonstrated. Approximately 10 days later, he began to cough up a little blood. His platelet count was 8 x 10⁹/L; prothrombin time was normal. The infiltrate seen on chest radiographs had extended, and a perihilar infiltrate had developed on the right side. Mild hemoptysis persisted despite multiple transfusions of platelet concentrates and administration . . . [Full Text of this Article]

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