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The search for an adequate diagnostic strategy for pulmonary embolism (PE) still causes controversy. The conventional diagnosis is made on the basis of clinical probability, pulmonary scanning, evidence of deep venous thrombosis (DVT), and pulmonary arteriography (PA) as the "gold standard."¹ The D-dimer^2-5 and helical computed tomography⁶ are new studies that can improve the diagnostic strategy and obviate unnecessary arteriographs.

The work of Ilana Kutinsky et al⁷ is an excellent contribution to this field, although in this case it is negative toward the value of the D-dimer latex study as a discriminating diagnostic tool in the diagnosis of PE, especially as the diagnosis correlates with that of PA. Nonetheless, their results do not contradict experiences of other groups who find that the D-dimer latex study is a less sensitive measure than the enzyme-linked immunosorbent assay (ELISA) method (correspondence of only 80%).²

We analysed D-dimer by ELISA, latex, and fibrinogen degradation . . . [Full Text of this Article]

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