You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 160 No. 14, July 24, 2000 TABLE OF CONTENTS
  Archives
  •  Online Features
  Editor's Correspondence
 This Article
 •Full text
 •PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citing articles on ISI (1)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Drug-Induced Allergic Cytopenia: In Vitro Confirmation by the Lymphocyte Transformation Test

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We want to continue the discussion on drug-induced agranulocytosis and neutropenia1-2 and point to the differentiation between underlying allergic or cytotoxic mechanisms that may be important: preventing allergic reactions usually requires avoidance of the culprit drug for a lifetime. The in vitro lymphocyte transformation test has proven more sensitive than skin tests for the diagnosis of drug allergy, and is effective regardless of the clinical phenotype of the reaction because drug-sensitized lymphocytes are found in antibody- or cellular-mediated immune reactions.3

Here we describe a 38-year-old man with Streptococcus viridans endocarditis of the mitral valve who began treatment with 80 mg of gentamicin 3 times daily and 2 g of ampicillin 3 times daily, which was changed on day 4 to 6 g of benzylpenicillin 3 times daily and 220 mg of gentamicin once daily. From day 22 on he developed a fever (39.8°C) and arthalgia. Cell counts gradually dropped and . . . [Full Text of this Article]







HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2000 American Medical Association. All Rights Reserved.